Avtor/Urednik		Dodič-Fikfak, Metoda
Naslov		Lung cancer and exposure to chrysotile and amphiboles: submitted in partial fulfillment of the requirements for the degree of doctor of science in work environment University of Massachusetts lowell
Tip		monografija
Kraj izdaje		Lowell
Založnik		University of Massachusetts
Leto izdaje		1998
Obseg		str. 180
Jezik		eng
Abstrakt		Considerable controversy surrounds the quenstion of whether the two different types of asbestos - amphiboles and chrysotile - have different carcinogenic potencies. The "amphibole hypothesis" holds that chrysotile is less likely to cause lung cancer and mesothelioma than are the amphiboles. Some researchers have even argued that chrysotile is not carcinogenic. The ability to clarify this question is limited by a lack of quantitative data with which to estimate separate dose-response curves for the two fiber types. This work investigated lung cancer risk in a Slovenian asbestos cement plant in which excellent historical exposure data are available to distinguish the working lifetime exposures of the two broad classes of asbestos fibers for workers in the plant. Detailed historical exposure reconstruction and a case control study of lung cancer incidence were conducted. The cohort of workers employed in the asbestos cement manufacturing plant of Salonit Anhovo, Slovenian was constructed from existing detailed wage lists which date from the 1940s. Cases were all incident cases of primary lung cancer from 1964 to 1994 in those who were hired after 1959 and who worked at least one month between 1964 and 1994. They were identified using data from the Slovenian National Cancer Registry, one of the oldest national registries in Europe. Exposure measurements were available for all exposed jobs beginning in 1961. Three different methods of measurement were used: konimeter measuring particles/cmj3, a gravimetric method measuring milligrams/m3, and membrane filter measuringfibers/cm3. Operation -specific conversion factors among these methods were developed to standardize the available airborne asbestos measurement.(Abstracts truncatet at 2000 characters)
Deskriptorji		LUNG NEOPLASMS OCCUPATIONAL EXPOSURE ASBESTOS CASE-CONTROL STUDIES ASBESTOS, AMPHIBOLE INCIDENCE AIR POLLUTANTS SMOKING LOGISTIC MODELS