Avtor/Urednik		Krajnc, I; Vizjak, A; Hvala, A; Jurčić, V; Rozman, B
Naslov		Bedeutung der histopathologiscen Analyse der Hautlaesionen bei Skleromyxoedem: Lichtmikroskopie, Elektronenmikroskopie, Immunhistochemie und Immunfluoreszenzmikroskopie
Prevedeni naslov		Significance of the histopathologic analysis of cutaneous lesions in scleromyxedema: light microscopy, electron microscopy, immunohistochemistry and immunofluorescence
Tip		članek
Vir		Acta Med Austriaca
Vol. in št.		Letnik 25, št. 3
Leto izdaje		1998
Obseg		str. 109-12
Jezik		ger
Abstrakt		Scleromyxedema (SM) may be considered as a possible disease entity in the differential diagnosis of scleroderma. Clinical data and the results of light, immunohistochemical, immunofluorescence and electron microscopic study of skin biopsies taken from a 53-year old patient with SM are reported. In the patient with SM in which abnormal serum paraprotein was not identified, the skin biopsy showed mucinous material in the dermis and proliferation of fibroblasts accompanied by mild dermal sclerosis. Immunofluorescence showed scanty granular IgG along the epidermal basement membrane and IgG and C1q focally along the connective tissue fibres in the dermis of clinically involved skin. In addition to clinical findings, detalied skin biopsy studies including contemporary techniques can contribute to the diagnosis of the disease.
Deskriptorji		SCLERODERMA, CIRCUMSCRIBED MYXEDEMA BIOPSY IMMUNOHISTOCHEMISTRY MICROSCOPY, ELECTRON FLUORESCENT ANTIBODY TECHNIQUE