Avtor/Urednik		Kos, Janko; Lah, Tamara T
Naslov		Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review)
Tip		članek
Vir		Oncol Rep
Vol. in št.		Letnik 5, št. 6
Leto izdaje		1998
Obseg		str. 1349-61
Jezik		eng
Abstrakt		Lysosomal cysteine proteinases, the cathepsing (CATS) belong to the papain family of proteinases, sharing a similar protein structure and mechanism of action. Subtle structural differences between these enzyme give rise to important variations in substrate specificity and specificity of inhibition by their endogenous inhibitors, the cystatins, stefins and kininogens under physiological and pathological conditions. Alterations in their expression, processing and localization have been observed at various levels in malignant human tumor tissue compared to normal and benign tissue counterparts. We have proposed that an imbalance between cathepsins and cystatins, associated with metastatic tumor cell phenotype, may facilitate tumor cell invasion and metastasis. The results of clinical investigations on cysteine cathepsins and their endogenous inhibitors in human breast, lung, brain and head and neck tumors, as well as in body fluids of ovarian, uterine, melanoma and colorectal carcinoma bearing patients, have shown that these molecules are highly predictive for the length of survival and may be used for assessment of risk of relaps and death for cancer patients. Their application for diagnosis, follow-up and the anticancer therapy has also been proposed.
Deskriptorji		NEOPLASMS CYSTEINE PROTEINASES CYSTEINE PROTEINASE INHIBITORS CYSTATINS DISEASE PROGRESSION PROGNOSIS BREAST NEOPLASMS LUNG NEOPLASMS HEAD AND NECK NEOPLASMS MELANOMA COLORECTAL NEOPLASMS CATHEPSINS ALPHA-MACROGLOBULINS