Avtor/Urednik		Turel, Matjaž; Šuškovič, Stanislav
Naslov		Mediatorji eozinofilnega granulocita in astma
Prevedeni naslov		The mediators of the eosinophil granulocyte and asthma
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 37, št. Suppl 5
Leto izdaje		1998
Obseg		str. 75-83
Jezik		slo
Abstrakt		Bacground. Asthma is a chronic inflammatory disorder of the airways in which many cells play a role, including eosinophils. In the systemic steroid dependent asthamics is the main goal to reduce steroid side effects with other effectively anti-inflemmatory drug. Cyclosporine A is an immunosupresive drug with potentially beneficial effect on inflammated airways. The main goal of this study was to find out if low doses cyclosporin A in a one week treatment has an influence on serum eosinophils cation protein concentration and number of eosinophils in blood. Patients and methods. We treated one week 12 systemic steroid dependent asthmatics (group A) with cyclosporine A (2mg/kg/day), 8 asthmatics (the first control group) withouth regulary use of the systemic corticosteroids with 40 mg methylprednisolone daily (group B). 8 healthy atopics withouth asthma history (group C) was the second control group. In the groups A and B we have collected blood samples every four hours the day before and the last day of the treatment. We performed measurements in the group C only one day. In the group A we registered at the same times blood concentration of the cyclosporine A. Results. In the group A did not significantly change the serum eosinophilic cation protein concentration and number of eosinophils. There were find no corelations between blood concentration of the cyclosporine A and serum eosinophilic cation protein concentration or number of eosinophils. In the group B we found statistically significant(p<0,05) differences in the serum eosinophilic cation protein (at $ pm, 8 PM and 4 AM) and number of eosinophils (all samples) before and after the treatment with methylprendisolone. Conclusions. We conclude that short treatment with the low doses of the cyclosporine A did not have an important influence on the serum eosinophilic cation protein concentrations and number of eosinophils in blood. (Abstract truncated at 2000 characters)
Izvleček		Izhodišča. Vnetje dihalnih poti s pomembnim deležem eozinofilnih granulocitov je glavna patofiziološka zančilnost astme. Za zdravljenje bolnikov z astmo, trajno odvisnih od zdravljenja z sistemskimi steroidi, poskušajo najti ustreznejše protivneto zdravilo. Eno od takih zdravil naj bi bil imunosupresivno zdravilo cliklospirin A. Skušali smo ugotoviti, ali kratkotrajno zdravljenje z nizkimi odmerki ciklosporina A vpliva na število eozinofilnih granulocitov v krvi in na serumsko koncentracijo eozinofilnega kationskega proteina, ki ga sproščajo aktivirani eozinofilni granulocidi. Preiskovanci in metode. S ciklosporinom A (2 mg/kg telesne teže/dan) smo zdravili 12 bolnikov z astmo, trajno odvisnih od zdravljenja s sistemskimi steroidi (skupina A). Primerjali smo jih s skupino 8 bolnikov z astmo (skupina B), ki vsaj 7 dni pred raziskavo niso prejemali sistemskih kortikosteroidov in smo jih med raziskavo zdravili s 40 mg metilprednizolona dnevo (skupina B). Drugo kontrolno skupino je predstavljalo 8 zdravih atopikov brez kliničnih znakov astme (skupina C). V skupini A in B smo dan pred začetkom zdravljenja vsake štiri ure določali serumsko koncentracijo eozinofilnega kationskega proteina in število eozinofilnega kationskega proteina in število eozinofilnih granulocitov v krvi, v skupini C pa na dan raziskave. V skupini A smo ob istih urah merili tudi koncentracijo ciklosporina A v krvi. Rezultati. V skupini A ciklosporin A ni statistično pomembno vplival na serumsko koncentracijo eozinofilnega kationskega proteina in število eozinofilnih granulocitov v krvi. Nismo našli povezav med koncentracijo ciklosporina A v krvi in serumsko koncentracijo eozinofilnega kationskega proteina ali številom eozinofilnih granulocitov. (Izvleček prekinjen pri 2000 znakih)
Deskriptorji		ASTHMA CYCLOSPORINE EOSINOPHILS METHYLPREDNISOLONE