Avtor/Urednik		Logar, Mateja
Naslov		Ali prisotnost Borreliae burgdorferi sensu lato vpliva na klinično sliko erythema migrans?
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		1998
Obseg		str. 66
Jezik		slo
Abstrakt		Lyme borreliosis is an endemic disease in Slovenia. It is the most common tick-borne human infection in Europe and USA. Lyme disease is caused by B. burgdorferi sensu lato. Early disease is characterised by a typical skin rash - erythema migrans, which enables the early clinical diagnosis and prompt antibiotic treatment. In this study we wanted to examine the hypothesis that the course of the erythema migrans is more severe in patients in whom spirochetes were isolated from the skin. For the successful isolation there should be a sufficient number of the causative organisms in skin. Beside that we wanted to find out how often blood cultures are positive for the presence of spirochetes in patients with EM and what is the course of EM in patients in whom spirochetes were isolated from the blood. 546 adult patients, with clinical diagnosis of EM in whom skin biopsy was performed and tissue specimen and blood were cultured in MKP medium for the presence of B. burgdorferi sensu lato, were included in the prospective clinical study, which was held at the Department of Infectious Diseases in Ljubljana from January 1 to December 31. The isolation of B. burgdorferi sensu lato was successful in 235 (43%) and in 311 (57%) patients we failed to isolate spirochetes from skin. In both groups females predominated. Females were also significantly older than males (p = 0,01 in the group with successful and p = 0,004 in the group with unsuccessful isolation of spirochetes from skin). There were no differences in age and sex between groups. 140 (59,6%) patients with successful and 197 (63,3%) with unsuccessful isolation of spirochetes from skin recalled a tick bite. 11,1 % with positive and 9,6% patients with negative skin cultures quoted an insect bite. Most of the patients in both groups noticed EM in July. (Abstract truncated at 2000 characters)
Deskriptorji		ERYTHEMA CHRONICUM MIGRANS BORRELIA BURGDORFERI SEX FACTORS AGE FACTORS BIOPSY SERODIAGNOSIS IGM IGG