Avtor/Urednik		Hafner, Matjaž
Naslov		Hepatocelularni karcinom (HCK): patohistološka analiza HCK in spremljajočih sprememb v jetrih
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		1996
Obseg		str. 45
Jezik		slo
Abstrakt		The autopsy reports, clinical records and liver tissue specimens of patients with hepatocellular carcinoma (HCC) who underwent post- mortem examination at the Institute of Pathology in Ljubljana in the period 1985 - 1994 were retrospectively reviewed to assess the epidemiological, clinical and pathomorphological characteristics of HCC in Slovenia. Fifty cases of HCC were documented in a total of 10.70l autopsy reports dating from the period covered by the survey. In the study population, HCC developed mostly in the 6th decade of life (32%) and was 3.5 times more common in men than in women. The great majority of patients (84%) had associated liver cirrhosis, the cause of which was mostly unknown during life. In patients with known etiology, the predominant cause was alcohol. Chronic hepatitis B infection was less common in our patients with HCC (8%) than in other comparable populations in southern and western Europe. The detection of chronic hepatitis C infection was not yet possible during the study period, and so its relation to HCC could not be evaluated. Only a smll proportion of HCC cases (28%) were diagnosed on clinical grounds before death. According to the macroscopic growth pattern, HCC occured most often in the form of a multinodular tumour (47%). Solitary small lesions measuring less than 3 cm in diameter were extremely rare (4%). Diffuse and massive tumours accounted for 16% of the cases each. Comparison of the macroscopic growth pattern with the tumour size, histological growth pattern and histological grade did not reveal any significant relationships aside from a significantly greater average diameter manifested by massive tumours as compared to other forms. According to histological grading, most of the carcinomas were moderately differentiated (73%), 21 % were well differentiated and only 6% were poorly differentiated. (Abstract truncated at 2000 characters)
Deskriptorji		LIVER NEOPLASMS CARCINOMA, HEPATOCELLULAR AGE FACTORS SEX FACTORS AUTOPSY NEOPLASM STAGING