Avtor/Urednik		Zorc, Metka
Naslov		Pathohistological changes of coronary arteries in diffuse and distal coronary artery disease
Tip		članek
Vir		In: Pajer Z, Štiblar-Martinčič D, editors. International symposium on cardiovascular diseases. Proceedings of the 29th memorial meeting devoted to prof. dr. Janez Plečnik; 1998 Dec 3-5; Ljubljana. Ljubljana: Medical faculty, Institute of histology and embryology,
Leto izdaje		1998
Obseg		str. 39-46
Jezik		eng
Abstrakt		The aim of the article was to investigate different types of atherosclerotic lesions in endarterectomy sequesters of coronary arteries. The role and importance of immunolgical deposits and cellular compositions in arterial wall were analysed. The study included 120 patients undergoing coronary endarterectomy. Sequesters were cut in step serial sections and histologicaly, immunohistologicaly and morphometricaly analysed. By using statistical methods and correlation analysis the results were compared with risk factors. Immunohistoligical analysis showed in half of investigated sequesters the presence offibrin - fibrinogen in tunica intima and media. Deposits of IgG and IgM were spread mainly focally in arterial wall. Intensive mononuclear infiltration in tunima and media, as well as mast cells inthe border between tunica intima and media were found. Risk factor analysis presented the highest volume density of mononuclear infilrates in patients with hyperlipoproteinemia type III and IV, as well as the highest numerical density of mast cells in hyperlipoproteinemia type II a, II b and in hipertension. Conclusion: - The presence of immune deposits and mononuclear infiltrates prove the hypothesis that atherosclerosis in diffused and distal artery disease could be an immune mediated disease. - Most cells play the important role in the pathogenesis of the disease, but their function is still controversial. - The influences of risk factors are specific and reflected in the morphological composition of vessel wall.
Deskriptorji		CORONARY DISEASE CORONARY ARTERIOSCLEROSIS ENDARTERECTOMY IMMUNOHISTOCHEMISTRY MAST CELLS LEUKOCYTES, MONONUCLEAR HYPERLIPOPROTEINEMIA HYPERTENSION DIABETES MELLITUS