Avtor/Urednik		Petrovič, Danijel; Peterlin, Borut
Naslov		Genetic polymorphism and coronary artery disease
Tip		članek
Vir		In: Pajer Z, Štiblar-Martinčič D, editors. International symposium on cardiovascular diseases. Proceedings of the 29th memorial meeting devoted to prof. dr. Janez Plečnik; 1998 Dec 3-5; Ljubljana. Ljubljana: Medical faculty, Institute of histology and embryology,
Leto izdaje		1998
Obseg		str. 71-8
Jezik		eng
Abstrakt		Coronary artery disease (CAD) is a complex disease trait or multifactorial genetic disorder, which appears to be due to interaction of multiple genetic and environmental factors. The recognition of a number of conventional environmental risk factors has led to important advances in the prevention and treatment of the disease. On the other hand, our knowledge of the genetic component of CAD is limited to observations of familial aggregation of CAD and predictive importance of a positive family history. Familial aggregation provided the first clue for a genetic component in predisposition to CAD. Advances in molecular genetics have provided a number of potential genetic risk factors for CAD. Appreciation of genetic polymorphisms- variants of genes in the candidate genes for CAD is the early stage in the elucidation of the molecular genetic basis of CAD. Functional variants of candidate genes of atherosclerosis of coronary arteries may be involved in the vascular homeostasis, hemostasis (thrombosis, fibrinolysis) and lipid metabolism. Clinical manifestations of these processes may be stable angina and its thrombotic complications, unstable angina and acute myocardial infarction. Genetic polymorphisms of the components, of the renin-angiotensin system (angiotensin-1-converting enzyme, angiotensinogen, angiotensin II, type-1 receptor gene), hemostatic factors (beta-fibrinogen, factor V and VII) and different apolipoproteins (E, A) are appreciated as candidate risk factors for CAD. Interaction of these variants of genes with environmental factors may after few decades results in angina pectois or myocardial infarction. Well designed, large-scale association studies are expected to evaluate the precise role of variants of candidate genes in the pathogenesis of CAD.(Abstract truncated at 2000 characters)
Deskriptorji		CORONARY DISEASE POLYMORPHISM (GENETICS) RENIN-ANGIOTENSIN SYSTEM PEPTIDYL-DIPEPTIDASE A ANGIOTENSINOGEN RECEPTORS, ANGIOTENSIN FACTOR V FACTOR VII APOLIPOPROTEINS RECEPTORS, LDL