Avtor/Urednik		Vižintin, Tjaša; Čižman, Milan
Naslov		Poraba in trendi protimikrobnega zdravljenja v Kliničnem centru v Ljubljani 1995-1997
Prevedeni naslov		Antimicrobial usage and trends in the University medical centre in Ljubljana from 1995 to 1997
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 67, št. 12
Leto izdaje		1998
Obseg		str. 721-5
Jezik		slo
Abstrakt		Background. To determine patterns and trends of antimicrobial usage in University Medical Centre in Ljubljana, Slovenia, from 1995 to 1997 before introduction of antibiotic guidelines and more accessible consultations of infectious diseases specialist. Methods. usage of antimicrobial drugs was determined retrospectively for the University Medical Centre as a whole and some of its units: Department of Paediatrics, Department of Infectious Diseases, Department of Surgery and Department of Internal Medicine. Drugs from JO1 group of anatomical therapeutical chemical classification system available in the Pharmacy of the University Medical Centre from 1995 to 1997 were included. Results were expressed as defined daily doses (DDD) per 100 bed days. Results. There was a 5.9% increase (43.68 in 1995 to 46.28 DDD/100 bed days in 1997) in overall antimicrobial drug use in the University Medical Centre over the studied period. Betalactam agents were most commonly used (53%), followed by macrolide and pyranozide antibiotics (13%) and quinolones (12%). In most units there was a trend towards increased use of macrolides, pyranozides and quinolones, whereas use of tetracyclines and amphenicole markedly decreased from 1995 to 1997. Conclusions. Overall consumption of antimicrobial drugs in the Uniersity Medical Centre is increasing. Differences in antimicrobial consumption between different units were found. Further studies are needed to determine the appropriateness of antimicrobial treatment and to continuously monitor antimicrobial usage.
Izvleček		Izhodišča. ugotoviti stanje in gibanje porabe protimikrobnih zdravil v Kliničnem centru v Ljubljani v obdobju 1995 do 1997 pred uvedbo enotnih priporočil in širše infektološke konzultacije. Metode. Retrospektivno smo ugotavljali porabo protimikrobnih zdravil v celotnem Kliničnem cenru ter naslednjih enotah: Pediatrična klinika, Klinika za infekcijske bolezni in vročinska stanja, Kirurške klinike in Interne klinike. Zajeli smo zdravila iz JO1 skupine po anatomsko-terapevtsko-kemijski klasifikaciji, ki so bila med letoma 1995 in 1997 na voljo v lekarni Kliničnega centra. Porabo protimikrobnih zdravil smo izrazili kot DDD (definirana dnevna doza) na 100 bolnišničnooskrbnih dni. Rezultati. Celokupna poraba protimikrobnih zdravil je v celotnem Kliničnem centru od leta 1995 do 1997 narasla s 43,68 na 46,28 DDD na 100 oskrbnih dni oziroma za 5,9%. Največji delež zavzemajo btalaktamski antibiotiki (53%), sledijo makrolidni in piranozidni antibiotiki (13%) ter kinolonske protimikrobne učinkovine (12%). V večini enot je prisoten trend naraščanja porabe makrolidnih, piranozidnih antibiotikov ter kinolonov in upad porabe tetraciklinov in amfenikolov. Zaključki. Poraba protimikbornih zdravil v Kliničnem centru narašča. Ugotovili smo razlike v porabi teh zdravil med posameznimi enotami. Potrebne so nadaljnje študije za ugotavljanje racionalnosti predpisovanja teh zdravil ter stalno spremljanje njihove porabe.
Deskriptorji		ANTI-INFECTIVE AGENTS ANTIBIOTICS DRUG UTILIZATION HOSPITALS HOSPITAL DEPARTMENTS