Avtor/Urednik		Olivetti, Giorgio; Cigola, Elena; Maestri, Roberta; Corradi, Domenico; Saccani, Gloria; Quaini, Federico
Naslov		The role of apoptosis in cardiovascular diseases
Tip		članek
Vir		In: Pajer Z, Štiblar-Martinčič D, editors. International symposium on cardiovascular diseases. Proceedings of the 29th memorial meeting devoted to prof. dr. Janez Plečnik; 1998 Dec 3-5; Ljubljana. Ljubljana: Medical faculty, Institute of histology and embryology,
Leto izdaje		1998
Obseg		str. 371-8
Jezik		eng
Abstrakt		Myocyte cell loss in the heart has been usually attributed to myocyte necrosis but recently myocyte apoptosis has been demonstrated to occur in several conditions including postnatal development, normal aging, myocardial ischemia and heart failure. Although difficulties exist in the distinction of myocyte cell death by necrosis and apoptosis, experimental techniques have been developed and used to measure the number of myocytes involved in these processes. DNA strand breaks, characteristic of the apoptotic death process, have been detected in situ by the terminal deoxynucleotidyl transferase assay and biochemically by agarose gel electrophoresis, whereas sarconemmal discountinuities have been evaluated by anti-myosin monoclonal antibody o detect necrotic myocytes. These studies have been able to provide new information on the incidence of the two process after myocardial infarction and in normal aging. Ischemia and mechanical stress are implicated in the activation of the apoptotic process, but apoptosis inmyocytes has been found in conditions without any stress or oxygen deprivation and in isolated myocytes exposed to atrial natriuretic peptide and angiotensin II. Downregulation or overexpression of molecular controller of apoptosis pertaining to the Bcl-2 family have been found in association with apoptotic myocyte cell death leaving the role played by these molecules still enigmatic. At present, myocyte apoptosis can be considered an essential determinant of several cardiac disorders and seems to play a significant role in the progression toward cardiac failure. Strategies to prevent apoptosis are promising, but there is still the need to evaluate in more deatilsthe specific pathways of myocyte apoptosis in order to minimize the drop off of contractile cells in different cardiac myopathies.
Deskriptorji		MYOCARDIAL ISCHEMIA APOPTOSIS PROTO-ONCOGENE PROTEINS C-BCL-2 AGING HEART FAILURE, CONGESTIVE