Avtor/Urednik		Us-Krašovec, M; Auersperg, M; Bergant, D; Golouh, R; Kloboves-Prevodnik, V
Naslov		Medullary carcinoma of the thyroid gland: diagnostic cytopathological characteristics
Tip		članek
Vir		Pathologica
Vol. in št.		Letnik 90
Leto izdaje		1998
Obseg		str. 5-13
Jezik		eng
Abstrakt		Sixty fine needle aspiration biopsy samples of the medullary carcinoma of the thyroid, 49 primary and 11 recurrent/metastatic, were reexamined in order to determine diagnostic features and value of auxiliary tehniques. In the smears, tumor cells were present either as single cells or in loose cohesive groups; in about one third of cases, threedimensional groups predominated. Cells were of different shapes round-to-oval, polihedral and spindle. The aspirates contained one or all three cell types. Large mononucleated cells were present in 47/60 cases and, in addition, in 34 of these multinucleated cells with nuclei arrayed in semicircular rows were present. Plasmacytoid and dentric cells, observed in 58/60 cases, apper to be an important diagnostic feature. Red cytoplasmic granules and amyloid deposits could serve as an additional diagnostic clue. Among the auxiliary techniques, the demonstration of calcitonin and CEA immunoreactive cells provided to be most helpfull.
Deskriptorji		THYROID NEOPLASMS CARCINOMA, MEDULLARY BIOPSY, NEEDLE IMMUNOHISTOCHEMISTRY DENDRITIC CELLS PLASMA CELLS