Avtor/Urednik		Stirn-Kranjc, Branka
Naslov		Pomen specifične zgradbe ekstraokularne mišice pri nekaterih živčnomišičnih boleznih in farmakoloških posegih
Prevedeni naslov		Imporatance of specific extraocular muscle structure in neuromuscular disease and pharmacological intervention
Tip		članek
Vir		In: Zbornik referatov 2. slovenski oftalmološki kongres; 1997 Sep; Portorož. Ljubljana: Združenje oftalmologov Slovenije,
Leto izdaje		1997
Obseg		str. 100-8
Jezik		slo
Abstrakt		Background. Extraocular muscle (EOM) as final effector of eye movements is a special muscle allotype. EOM exhibit considerable variation in muscle fibre size and types, high connective tissue content and special innervation: single and multiple. Different muscle fibre types may subserve greater functional ability such as vergence, saccadic, pursuit, vestibulo-ocular and optokinetic movements. Different sensorial function changes the ocular motor neuron activity what contributes to a new muscle fiber phenotype. Conclusions. The properties of EOM may explain the pedisposition or sparing of this muscle in neuromuscular disorders or pharmacological intervention like toxic degeneration with local anesthetics or toxic paralysis with Botulinum toxin. One potential mechanism for EOM protection in Duchenne muscular dystrophy might be the higher Capacity of EOM to scavenge free radicals due to higher specific ezyme activity. The involvement of EOM in myasthenia gravis might be related to the specific compromise of neural transmission in the multiply innervated fibre because of retained expression of the embryonic acetylcholine receptor isoform. Chronic progressive external ophthalmoplegia in the inherited mitochondrial cytopathy affects the EOM due to high oxidative energy metabolism. Thyroid disease specifically targets orbital fibroblasts. In EOM there is an abnormaf accumulation of glycosaminglycans in the connective tissue.
Deskriptorji		OCULOMOTOR MUSCLES NEUROMUSCULAR DISEASES BOTULINUM TOXIN TYPE A MUSCULAR DYSTROPHY MYASTHENIA GRAVIS ANESTHETICS, LOCAL