Avtor/Urednik		Strojan, Primož
Naslov		Napovedni pomen katepsinov in njihovih endogenih inhibitorjev pri bolnikih s karcinomi glave in vratu
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		1998
Obseg		str. 112
Jezik		slo
Abstrakt		Backgroud: Cathepsins are ubiquitous lysosomal proteolytic enzymes. Cathepsins B, H and L belong to the class of cystecine or thiol proteinases, while cathepsin D belong to the class of aspartic protinases. Cystacin (stefins A and B, cystacin C) are endogenous, i. e. physiological inhibitors of cysteine proteinases, while an endogenous inhibitor of the aspartic protease of cathepsin D has not been found yet. Along with other cells protinases and inhibitors, cathepsins and cystatins are involved in proteolytic process which lead to invasion and dissemination of tumor cells. Therefore it is possible that their concentration in serum or tumor tissue cytosol correlates with the malignant potential of tumors and predicts the patient's survival. A correlation with patients' survival has been established particulary in the case of cathepsin D and breast cancer, where an increased cathepsin D expression is associated witha worse prognosis. In patients with other types of malignant tumors or in the case of other cathepsins is less clear. Aim: Our study was aimed to evaluate the prognostic value of cathepsins D, B, H and L, stefins A and B, and cystatin C in patients with carcinomas of the head and neck. (Abstract truncated at 2000 characters)
Deskriptorji		HEAD AND NECK NEOPLASMS CATHEPSINS CYSTATINS CATHEPSIN B CATHEPSIN D ENZYME-LINKED IMMUNOSORBENT ASSAY PROGNOSIS