Avtor/Urednik		Scherberger, Hansjoerg; Leder, Ortwin
Naslov		A planar model of hepatic blood flow potential
Tip		članek
Vir		Acta Stereol
Vol. in št.		Letnik 17, št. 3
Leto izdaje		1998
Obseg		str. 343-52
Jezik		eng
Abstrakt		We present a two-dimensional model of hepatic blood flow potential that takes afferent and efferent venous vessels and the sinusoidal capillary network into account. Congrucnt equilateral triangles were chosen as units. Planar patterns of such triangles. can be interpreted in terms of the classical hexagonal liver lobule, a complementary bile lobule, and of Rappaport's acinus. Model assumptions include a fixed terminal portal and hepatic venous pressure and a fixed distribution of flow conductivity inside the planar unit. Simulated pressure potentials differed substantially for the physiologic condition and for liver congestion. The model corresponds to the planar distribution of glucose-6-phosphatase activity and demonstrates an intimate relationship between hepatic microcirculation and metabolic heterogeneity. Furthermore, in simulations of liver congestion, predicted alterations of intralobular pressure reflected changes of liver morphology, thus suggesting a causal association between both processes.
Deskriptorji		LIVER HEPATIC VEINS MODELS, THEORETICAL