Avtor/Urednik		Ravnik-Glavač, Metka; Mašera, Andrej; Ovčak, Zdenka; Glavač, Damjan
Naslov		Methylation of the von Hippel-Lindau (VHL) tumor suppressor gene in renal cell carcinoma (RCC)
Tip		članek
Vir		In: Osmak M, Škrk J, editors. Molecular oncology today. Proceedings of the Croatian-Slovenian meeting; 1995 Dec 19; Zagreb. Zagreb: Croatian ligue against cancer,
Leto izdaje		1996
Obseg		str. 29-33
Jezik		eng
Abstrakt		Changes in the pattern of DNA methylation have been a consistent finding in cancer cells. Fourteen kidney tumors with no somatic mutation in the VHL locus were examined for methylation changes in 5'CpG island of exon 1. In 8 clear cell tumors hypermethylated cytosines were identified while no hypermethylation sites were observed in 6 papillary tumors. These results suggest that methylation of the VHL gene represents another important mechanism of tumor suppressor gene inactivation.
Deskriptorji		HIPPEL-LINDAU DISEASE CARCINOMA, RENAL CELL GENES, SUPPRESSOR, TUMOR KIDNEY NEOPLASMS DNA METHYLATION POLYMERASE CHAIN REACTION POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL