Avtor/Urednik		Stopar, Tatjana
Naslov		Vpliv proporcionalno asistirane ventilacije (PAV) na način dihanja in dihalno delo bolnikov s stabilno kronično obstruktivno pljučno boleznijo (KOPB)
Tip		monografija
Kraj izdaje		1998
Založnik		Medicinska fakulteta
Leto izdaje		1998
Obseg		str. 20
Jezik		slo
Abstrakt		Objectives: Proportional assist ventilation was designed to reduce the insipiratory effort used to overcome respiratory resistence (RRS) and elastence (ERS) by applying pressure in proportion to flow (Flow asist, FA) and volume (Volume assist, VA). The first aim of this study was to determine the effects of systematically varying the level of assisitance provided with PAV using combined FA and VA on breathing pattern and inspiratory effort in subjects with severe COPD. The second aim was to specifically examine the interaction between FA and VA by comparing results obtained at the highest level of assisitance when FA and VA were applied either separately or in combination. Subjects:10 stable patient with severe COPD (FEV1<1L). Methods: Flow, volume, esophageal (Pes) and transdiaphragmatic (Pdi) pressure were measured during spontaneous breathing (Control) and PAV trials. Inprotocol #1, PAV was applied using combined FA and VA at 20%, 40% of ERS and RRS, respectively. In protocol #2, the interaction between FA and VA was examine by comparing results at the highest level of assisitance only (80%) for FA alone, VA alone, and combined FA+VA. Results: Compared to the spontaneous breathing (Control), lower levels of PAV (20-40%) using combined FA+VA significantly reduced (p<0.05) inspiratory effort, as reflected by the pressure-time integral of the diaphragm (Pdi. dt) and the inspiratory muscles (Pmus. dt). This occured with little change in breathing pattern. The ligher levels of combined FA+VA further reduced inspiratory effort, but this was associated with a significant increase in tidal volume (VT) (p<0.05), and lesser changes in respiratory rate (RR) and minute ventilation (VE).(Abstract truncated at 2000 charaters)
Deskriptorji		LUNG DISEASES, OBSTRUCTIVE RESPIRATORY MECHANICS RESPIRATION, ARTIFICIAL TIDAL VOLUME LUNG VOLUME MEASUREMENTS RESPIRATORY MUSCLES