Avtor/Urednik		Petelin, Milan; Šentjurc, Marjeta; Stolič, Zorka; Skalerič, Uroš
Naslov		EPR study of mucoadhesive ointments for delivery of liposomes into the oral mucosa
Tip		članek
Vir		Int J Pharm
Vol. in št.		Letnik 173, št. 1-2
Leto izdaje		1998
Obseg		str. 193-202
Jezik		eng
Abstrakt		Local drug delivery to the oral cavity tissues has been used for treatment of periodontal disease, apthosus stomatitis, lichen planus, bacterial and fungal infections. The liposome stability in different mucoadhesive ointments, their transort into dog's oral mucos aand gingiva and washing out of ointments from tisue surface was investigated by electron paramagnetic resonance (EPR). Liposomes were composed of soya lecithin, cholesterol and lipoaminosalt (55:35:10 w/w) and encapsulated with spin labeled water soluble spin probe ASL (N-1-oxyl-2.2.6.6-tetramethyl-4-piperidinyl-N-dimenthyl-N-hydroxyethylammonium iodide). Polymethyl methacrylate, carbopol 934P and orabase as the bioadhesive ointments were used. The stability of lipoomes did not change significantly after mixing with polymethyl methacrylate, but decreases in Carbopol and even more in Orabase. Washing out expirement shows that all three ointments adhere well to oral mucosa and gingiva. After 10 min of washing, approximately 30% of hydrogels were washed out. The transport experiment showed that liposomes limit the transport of hydrophilic substance to the superficial layer of epithelium. In oral mucosa, as apposed to gingiva, hydrogels enhance the transport as compared to solution of ASL or liposomes. Among the examined ointments, polymethyl methacrylate proved to be the most appropriate for local application of liposome entrapped drug to oral mucosa or gingiva.
Deskriptorji		DRUG DELIVERY SYSTEMS MOUTH MUCOSA GINGIVA LIPOSOMES OINTMENTS DOGS MOUTH DISEASES ELECTRON SPIN RESONANCE SPECTROSCOPY METHACRYLATES DRUG STABILITY ADMINISTRATION, TOPICAL