| Avtor/Urednik | Vizjak, Alenka; Ferluga, Dušan; Nagode, Breda; Koselj-Kajtna, Mira; Rozman, Blaž | |
| Naslov | Significance of antineutrophil cytoplasmic antibodies (ANCA) in the classification of glomerulonephritis | |
| Prevedeni naslov | Značaj antineutrofilnih citoplazmatskih protutjela (ANCA) u dijagnostici glomerulonefritisa | |
| Tip | članek | |
| Vir | Acta Med Salin | |
| Vol. in št. | Letnik 27, št. Suppl 1 | |
| Leto izdaje | 1998 | |
| Obseg | str. 53-7 | |
| Jezik | eng | |
| Abstrakt | Antineutrophil cytoptasmic antibodies (ANCA) are a useful marker in the diagnosis of pauci-immune necrotizing crescentic glomerulonephritis with or without systemic vasculitis. These autoantibodies are directed against various cytoplasmic antigens of neutrophil granulocytes and monocytes, the most frequent being proteinase 3 and myeloperoxidase. Two staining pattems are recognized by indirect immunofluorescence: cytoplasmic and perinuclear. ELISA enables the determination antibodies' antigen specificity. Antibodies with specificity for proteinase 3 are highly sensitive for Wegener's granulomatosis and anti-myeloperoxidase antibodies are characteristically found in patients with microscopic polyaniitis and pauci-immune creseentic glomerulonephritis. The term ANCA associated diseases has generally been accepted. However, ANCA can occasionally be positive in various other diseases. mostly in low values. with an atypical immunofluoreseence pattern and specificity for iiiyeloperoxidase or unknown antigen. | |
| Deskriptorji | GLOMERULONEPHRITIS ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC VASCULITIS WEGENER'S GRANULOMATOSIS ENZYME-LINKED IMMUNOSORBENT ASSAY FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT |