Avtor/Urednik		Jarm, Tomaž; Kaung, Marie; Serša, Gregor; Čemažar, Maja; Kragelj, Rudi; Miklavčič, Damijan
Naslov		Modified clonal resistance model of tumor electrochemotherapy in mice
Tip		članek
Vir		In: MEDICON '98. Proceedings of the 8th Mediterranean conference on medical and biological engineering and computing; 1998 Jun 14-17; Lemesos. Lemesos: University of Cyprus,
Leto izdaje		1998
Obseg		str. 1-5
Jezik		eng
Abstrakt		Multi-directional electrochemotherapy is a variation of electrochemotherapy (ECT) in which one set of electric pulses is applied inone direction and another set of pulses in different direction, in the presence of a chemotherapeutic drug. Recent experiments have shown that this treatment yields beter results in fraction of tumor cells killed, and longer growth delay of cells that remain, but the underlying mechanisms are still unknown. In determining a mathematical model with which to predict the results of such a therapy, it has been shown that the mechanism is not a simple matter of permeabilizing the same fraction in two consecutive treatments. This model would predict better resulst than actual experimental results. This would indicate that there is a factor which inhibits the fraction of cells remaining after the first treatment from being permeabilized as easily during the second treatment.
Deskriptorji		ELECTRIC STIMULATION THERAPY CARCINOMA, EHRLICH TUMOR MICE, INBRED CBA CELL DEATH MODELS, THEORETICAL