Avtor/Urednik		Hellquist, H; Cardesa, A; Gale, N; Kambič, V; Michaels, L
Naslov		Criteria for grading in the Ljubljana classification of epithelial hyperplastic laryngeal lesions. A study by members of the Working group on epithelial hyperplastic laryngeal lesions of the European society of pathology
Tip		članek
Vir		Histopathology
Vol. in št.		Letnik 34, št. 3
Leto izdaje		1999
Obseg		str. 226-33
Jezik		eng
Abstrakt		Aims: To validate histological criteria for the grading of epithelial hyperplastic Laryngeal lesions (EHHL) (dysplastic laryngeal lesions), we used a system that had been devised and tested in Ljubljana. Slovenia over many years and was felt to be more appropriate to laryngeal pathology than is the commonly-used model of intraepithelial neoplasia in the cervix. Methods and results: Vocal cord biopsies of 45 patients with a broad spectrum of EHLL were revfewed. Detailed histological criteria were formulated for each of the four grades of EHLL in the Ljubljana classifcation, comprising simple hyperplasia (benign spineus layer augmentation), abnormal hyperplasia (benign basal and parabasal layer augmentation), atypical hyperplasia (risky for malignancy) and carcinoma in situ (actually malignant. but without invasion). Conclusions: Using these criteria a high degree of concordance of histological diagnoses of grading levels for the Ljubljana classification was achieved between the pathologists of the Working Group. The system was found to be more precise for routine diagnostic work than the others in vogue. The different grades of the Ljubljana classification correspond to significantly different levels yielded in each grade by the semiobjective methods of quantitative morphometry and immunohistochemistry.
Deskriptorji		LARYNGEAL DISEASES LARYNGEAL MUCOSA LARYNGEAL NEOPLASMS PRECANCEROUS CONDITIONS EPITHELIUM HYPERPLASIA KERATIN MULTICENTER STUDIES SLOVENIA