Avtor/Urednik		Salonen, Reijo; Saiers, Jane
Naslov		Treatment of migraine: selective 5HT1 agonists in 1999
Prevedeni naslov		Zdravljenje migrene: selektivni agonisti 5HT1 v letu 1999
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 38, št. Suppl 4
Leto izdaje		1999
Obseg		str. 83-92
Jezik		eng
Abstrakt		Sumatrpitan is the first medication specifically developed to treat migraine, and the first 5TH, agonist shown to be effective with a demonstrated clinical safety profile. Sumatriptan is available in tablet, nasal spray, injectable, and in some countries, suppository formulations. In controlled studies, approximately 80% of patients treated with sumatriptan injection (6 mg) and 70% of patients treated with sumatriptan tables (25 mg, 50 mg, 100 mg) or sumatriptan nasal spray (20 mg) experience pain relief 2 hours after dosing. The times to onset of action for pain relief with sumatriptan injection, nasal spray, and tablets are 10 minutes, 15 minutes, and 30 minutes, respectively. A number of other 5TH, agonists such as naratrptan, zolmitriptan, rizatriptan have recently been introduced in tablet form for the acute treatment of migraine. Experience with the newer 5TH, agonist tablets to date suggests that, generally speaking, they have similar peak efficacies and times to onset of action to those of sumatriptan talbets, with no tablet showing an onset of action before 30 minuts postdose. The availability of multipe 5TH, agonist tablets and the choice of formulations with sumatriptan allow the clinician to tailor therapy to the needs of the individual patient.
Izvleček		Sumatriptan je prvo zdravilo, ki je bilo specifično razvito za zdravljenje migrene, in prvi učinkovit agonist 5HT, z dokazano klinično varnostjo. Sumatriptan je dostopen v obliki tablet, nosnega pršila, injekcij in v nekaterih državah v obliki svečk. V kontroliranih kliničnih študijah je približno 80% bolnikov, zdravljenih s sumatriptanom v injekciji (6 mg) in 70% bolnikov, zdravljenih s tabletami sumatriptana (25 mg, 50 mg, 100 mg) ali sumatriptanom v obliki nosnega pršila (20 mg), čutilo olajšanje bolečine 2 uri po aplikaciji zdravila. Injekcija sumatriptana začne delovati po 10, nosno pršilo po 15 in tablete po 30 minutah. Za zdravljenje migrene je bilo v zadnjem času uvedenih več drugih agonistov 5TH, v obliki tablet, na primer naratriptan, zolmitriptan, zolmitriptan in rizatriptan. Izkušnje z novejšimi tabletami agonistov 5TH, kažejo, da imajo, splošno rečeno, podobno mksimalno učinkovitost in podben čas do začetka delovanja kot tablete sumatriptana. Nobena od tablet ne začne delovati prej kot 30 minutah po zaužitju. Dostopnost več različnih agonistov 5TH, v obliki tablet in različne farmacevtske oblike sumatriptana omogočajo kliniko, da zdravljenje prikroji potrebam posameznih bolnikov.
Deskriptorji		MIGRAINE SEROTONIN AGONISTS SUMATRIPTAN