Avtor/Urednik		Pirtošek, Zvezdan; Merello, Marcelo; Carlsson, Arvid; Stern, Gerald
Naslov		Preclamol and parkinsonian fluctuations
Tip		članek
Vir		Clin Neuropharmacol
Vol. in št.		Letnik 16, št. 6
Leto izdaje		1993
Obseg		str. 550-4
Jezik		eng
Abstrakt		Preclamol, the (-)enantiomer of 3-PPP (=3(3-hydroxyphenyl)-N- n-propyl piperidine), has a selective dopamine autoreceptor- and postsynaptic mixed agonist-antagonist profile. Its action on patients with disabling on-off parkinsonian fluctuations has been studied and compared with those of placebo and subcutaneous apomorphine. Preclamol had a mild but unequivocal antiakinetic effect, less than that caused by subcutaneous apomorphine, but it provoked less dyskinesia. Further studies to explore the therapeutic potential of preclamol seem justified.
Deskriptorji		PARKINSON DISEASE ANTIPARKINSON AGENTS PIPERIDINES APOMORPHINE BLOOD PRESSURE DOPAMINE AGONISTS INJECTIONS, SUBCUTANEOUS MOVEMENT RECEPTORS, DOPAMINE D1 RECEPTORS, DOPAMINE D2