Avtor/Urednik		Marušič, Andrej
Naslov		Some relationships between standard biological and suggested psychosocial risk factors, and ischaemic heart disease
Tip		monografija
Kraj izdaje		London
Založnik		University of London
Leto izdaje		1997
Obseg		str. 251
Jezik		eng
Abstrakt		The objective of this research was to investigate simultaneously biological and psychosocial risk factors on groups of 187 ischaemic heart disease (IHD) patients, 19 atypical chest pain patients and 187 controls. Initially, the first and the third group were compared on main biological and hypothesised psychosocial risk factors: neuroticism, psychoticism, sensitisation, coronary-prone behaviour, emotional coping, and lack of personal autonomy. The final multivariate regression model confirmed 5 individual risk factors with sensitisation amongst them, and 4 risk factors' interactions including a synergism between neuroticism and smoking. It has been concluded that psychosocial coronary proneness plays an important role in predicting IHD, even after taking into account the main, most probably atherogenic, biological risk factors. Moreover, the existence of some biopsychosocial correlates of IHD risk factors was demonstrated by means of the principal component analysis and, according to these, two potential mechanisms of psychosocial pathogenicity have been suggested, notably alterations in health related behaviours and behaviourally evoked perturbations of neuroendocrine responses. Afterwards, relationships between extent and severity scores of atherosclerosis, and IHD risk factors were examined on the group of IHD patients only. A lack of significant associations between the psychosocial risk factors and the indicators of atherosclerosis development has suggested involvement of psychosocial risk factors at some other stages of the development of IHD. In fact, especially in smokers, psychosocial risk factors might be involved in sudden deteriorations in the coronary flow due to the vasoconstriction. Finally, the group with the atypical chest pain was found to be somewhere in-between IHD patients and controls as far as standard risk factors were concerned.
Deskriptorji		MYOCARDIAL ISCHEMIA CHEST PAIN ANGINA PECTORIS ANGINA, UNSTABLE MYOCARDIAL INFARCTION RISK FACTORS SMOKING ATHEROSCLEROSIS MULTIVARIATE ANALYSIS HYPERLIPIDEMIA HYPERTENSION HYPERGLYCEMIA INSULIN RESISTANCE OBESITY PERSONALITY TESTS STRESS, PSYCHOLOGICAL LIFE CHANGE EVENTS ANTHROPOMETRY