Avtor/Urednik     Salewski, Erich; Bassaris, Harry P; Calangu, Semra; Kitzes, Ruth; Kosmidis, John; Raz, Raul; Kompan, Lidija
Naslov     Cost-minimisation analysis of sequential treatment with ofloxacin or ciprofloxacin in hospitalised patients
Tip     članek
Vir     Pharmacoeconomics
Vol. in št.     Letnik 11, št. 4
Leto izdaje     1997
Obseg     str. 359-66
Jezik     eng
Abstrakt     This study evaluated the cost of sequential treatment with once-daily ofloxacin or twice-daily ciprofloxacin in 474 hospitalised patients in different countries. The patients were treated intravenously for at least 3 dats, then orally for 7 to 10 days or for 3 days beyond the disappearance of infection-related symptoms. The overall clinical cure rate (86.8% with ofloxacin and 89.6% with ciprofloxacin) and the overall bacteriological response rate (89.9 and 89.0%, respectively) were similar, and a cost-minimisation analysys was conducted. The aquisition costs for ofloxacin and ciprofloxacin in Greece, Israel, Slovenia and Turkey were used and voverted to Deutschmarks (DM), and the costs of administration were analysed for each hospital. The different cost categories for oral intravenous (IV) treatment (e.g. antimicrobial acquisition, drug monitoring, drug delivery costs) were used to identify and differences. The total costs per patient varied between the countries involved, but were higher for ciprofloxacin (ofloxacin: DM239 to DM724; ciprofloxacin: DM540 to DM976). In a sensitivity analysis using identical daily acquisition costs for the 2 fluoroquinolones, the total cost of treatment was higher for ciprofloxacin, as a result of the lower cost of administration of ofloxacin in the once-daily regimen. Continuing IV therapy would be approximately 50% more expensive than switching to oral administration; however, whenever possible, both drugs can be switched from IV to oral treatment.
Deskriptorji     BACTERIAL INFECTIONS
OFLOXACIN
CIPROFLOXACIN
DRUG COSTS
ADMINISTRATION, ORAL
INJECTIONS, INTRAVENOUS
HOSPITALIZATION
HEALTH CARE COSTS
TIME FACTORS
GREECE
ISRAEL
TURKEY
SLOVENIA