Avtor/Urednik | Salewski, Erich; Bassaris, Harry P; Calangu, Semra; Kitzes, Ruth; Kosmidis, John; Raz, Raul; Kompan, Lidija | |
Naslov | Cost-minimisation analysis of sequential treatment with ofloxacin or ciprofloxacin in hospitalised patients | |
Tip | članek | |
Vir | Pharmacoeconomics | |
Vol. in št. | Letnik 11, št. 4 | |
Leto izdaje | 1997 | |
Obseg | str. 359-66 | |
Jezik | eng | |
Abstrakt | This study evaluated the cost of sequential treatment with once-daily ofloxacin or twice-daily ciprofloxacin in 474 hospitalised patients in different countries. The patients were treated intravenously for at least 3 dats, then orally for 7 to 10 days or for 3 days beyond the disappearance of infection-related symptoms. The overall clinical cure rate (86.8% with ofloxacin and 89.6% with ciprofloxacin) and the overall bacteriological response rate (89.9 and 89.0%, respectively) were similar, and a cost-minimisation analysys was conducted. The aquisition costs for ofloxacin and ciprofloxacin in Greece, Israel, Slovenia and Turkey were used and voverted to Deutschmarks (DM), and the costs of administration were analysed for each hospital. The different cost categories for oral intravenous (IV) treatment (e.g. antimicrobial acquisition, drug monitoring, drug delivery costs) were used to identify and differences. The total costs per patient varied between the countries involved, but were higher for ciprofloxacin (ofloxacin: DM239 to DM724; ciprofloxacin: DM540 to DM976). In a sensitivity analysis using identical daily acquisition costs for the 2 fluoroquinolones, the total cost of treatment was higher for ciprofloxacin, as a result of the lower cost of administration of ofloxacin in the once-daily regimen. Continuing IV therapy would be approximately 50% more expensive than switching to oral administration; however, whenever possible, both drugs can be switched from IV to oral treatment. | |
Deskriptorji | BACTERIAL INFECTIONS OFLOXACIN CIPROFLOXACIN DRUG COSTS ADMINISTRATION, ORAL INJECTIONS, INTRAVENOUS HOSPITALIZATION HEALTH CARE COSTS TIME FACTORS GREECE ISRAEL TURKEY SLOVENIA |