Avtor/Urednik     Hermann, Dejan
Naslov     Histomorfologija in imunohistologija postinfekcijskega glomerulonefritisa v odvisnosti od trajanja bolezni in vrste okužbe
Prevedeni naslov     Histomorphology and immunohistology of postinfectious glomerulonephritis in relation to the duration of the disease and type of infection
Tip     članek
Vir     Med Razgl
Vol. in št.     Letnik 8, št. 3
Leto izdaje     1999
Obseg     str. 339-65
Jezik     slo
Abstrakt     In addition to the classical picture of endocapillary proliferative and exudative glomerulonephritis, patients with acute postinfectious glomerulonephritis may manifest a broad spectrum of various histomorphological and immunohistological changes which may reflect the stage of the disease, their responsivness to the disease and/or the specific type of infection. The data on the correlation between histomorphological changes and immune deposits are still sparse. The purpose of this study was to evaluate these, most probably key relationships in the pathogenesis related to the duration of the disease and type of infection. This retrospective study involved 113 kidney biopsies from 91 men and 22 women with the diagnosis of postinfectious glomerulonephritis. The tissue samples were examined by standard light and immunofluorescent microscopy techniques. Mesangial, endocapillary and mesangiocapillary proliferation, exudation, tubulo-interstitial changes, vascular lesions and glomerular immune deposits were evaluated semiquantitatively using the generally recognized nephropatological methods. Extracapillary proliferation and global and segment glomerulosclerosis were evaluated as a percentage of the affected glomeruli. Immune deposits demonstrated the following three immunofluorescent patterns: garland, starry sky and mesangial.
Izvleček     Pri bolnikih z akutnim postinfekcijskim glomerulonefritisom ugotavljajo poleg klasične histomorfološke slike endokapilarnega proliferacijskega in eksudacijskega glomerulonefritisa širok spekter histomorfološkega in imunohistološkega izražanja bolezni, ki je lahko posledica stadija bolezni, individualne odzivnosti in/ali razlik v vrsti okužbe. V dosegljivi literaturi so odnosi med histomorfološkimi spremembami in odlagami imunskih reaktantov opisani pomanjkljivo. Cilj raziskave je zato bil natančneje opredeliti le-te, v patogenezi verjetno ključne odnose v odvisnosti od trajanja bolezni in vrste okužbe. Retrospektivna raziskava je vključevala 113 ledvičnih biopsij 91 moških in 22 žensk, ki so izpolnjevali klinićne kriterije za diagnozo akutnega postinfekcijskega glomerulonefritisa. Vzorci ledvičnega tkiva so bili obdelani po standardni svetlobno in imunofluorescentno mikroskopski tehnologiji. V skladu z uveljavljeno metodologijo v nefropatologiji smo semikvantitativno ocenili stopnjo mezangijske, endokapilarne in mezangiokapilarne proliferacije, eksudacijske reakcije, tubulo-intersticijskih sprememb in sprememb na žilah ter glomerulnih imunskih odlag. Ekstrakapilarno proliferacijo, globalno in segmentno glomerulosklerozo smo ocenili v odstotkih prizadetih glomerulov. Glede na obliko imunskih odlag smo ugotavljali tri imunofluoresoenhie vzorce: ogrličast, vzorec zvezdnatega neba in mezangijski.
Deskriptorji     GLOMERULONEPHRITIS
STREPTOCOCCAL INFECTIONS
FLUORESCENT ANTIBODY TECHNIQUE, DIRECT
ANTIGEN-ANTIBODY COMPLEX