Avtor/Urednik		Petelin, M; Ivanuša, T; Pavlica, Z; Skalerič, U
Naslov		Obnova čeljustne kosti po lokalnem dovajanju superoksidne dismutaze
Prevedeni naslov		Local delivery of superoxide dismutase stimulates alveolar bone regeneration
Tip		članek
Vir		Zobozdrav Vestn
Vol. in št.		Letnik 54, št. 3-4
Leto izdaje		1999
Obseg		str. 97-104
Jezik		slo
Abstrakt		Plaque bacteria activate gingival phagocytes to produce oxygen-derived free radicals, which can cause extensive tissue damage. Superoxide has also been localised at the ruffled border space of osteoclasts, suggesting that it may be involved at the osteoclast-bone interface in matrix degradation. The aim of the study was to evaluate the use of local delivery of superoxide dismutase for alveolar bone regeneration. After 9 months of experimental periodontitis in five beagle dogs, ligatures were removed and all teeth were scaled supragingivally. In each animal, four different therapeutic modalities were used. The first quadrant received supragingival scaling only, the second supragingival scaling followed by liposome-encapsulated superoxide dismutase (SOD), the third scaling and root planing, and the fourth quadrant scaling and root planing followed by liposome-encapsulated SOD. The drugs were delivered subgingivally with a syringe on a daily basis for a period of 6 weeks. Gingival index (GI), probing depth (PD) and clinical attachment level (CAL) were measured. Radiographs were evaluated at baseline and at the end of the treatment period. Analysis of the radiographs was performed using digital subtraction radiography. At the end of the treatment period, histometric analysis was done. Statistical analysis of data was performed by ANOVA, unpaired t-test and Tukey HSD test. The greatest improvement in GI, PD and CAL was found around teeth treated with scaling and root planing followed by SOD application. The treatment also showed the greatest alveolar bone apposition (10+-3.6%, p<0.05), the shortest distance between cementumenamel junction and alveolar bone level (p<0.05), and new bone formation. We can conclude that scaling and root planing followed by subgingival application of liposome encapsulated SOD stimulate regeneration of alveolar bone in beagle dogs.
Deskriptorji		SUPEROXIDE DISMUTASE PERIODONTAL INDEX PERIODONTITIS DOGS LIPOSOMES ALVEOLAR BONE LOSS