Avtor/Urednik		Jerše, M; Vizjak, A; Hvala, A; Rozman, B; Kos, M; Bren, AF; Ferluga, D
Naslov		Correlation between WHO classes and forms of glomerulonephritis in SLE
Tip		članek
Vir		In: Vizjak A, Rozman B, Ferluga D, editors. Autoimmune systemic diseases. Proceedings of the 30th memorial meeting for professor Janez Plečnik; 1999 Dec 2-3; Ljubljana. Ljubljana: Faculty of medicine, Institute of pathology,
Leto izdaje		1999
Obseg		str. 112-8
Jezik		eng
Abstrakt		Renal complications in SLE posses the greatest risk for morbidity and mortality. Efforts have been made to define the histological features important for therapy and prognosis of the disease. Among them of particular importance are glomerular changes. The aim of our study was to analyse different histomorphologic forms of GN in WHO classes, and to establish transformation from one WHO class and histologic type to another. Study included 370 biopsies from 267 patients with SLE examined by traditional light, immunofluorescent and electron microscopy. The WHO classes 1, If, V, and VI showed rather homogeneous histologic pattem, whereas classes III and IV were heterogeneous, and inc(uded following types of GN: endocapillary (WHO III / IV = 11.8% / 8.8%), membranoproliferative (WHO III / IV = ?.I% / l9%), extracapillary proliferation (WHO III / IV = 35.5% / 20%), mixed GN-membranous GN with prolifetstion Iesions (WHO III / IV = 29% / 53.5%). Subendothetiat and transmembranous pattem of immunc deposits prevailed in WHO class III and IV, and were associated with more unfavourablc clinical outcome, and corretated with activity index vatues. This immune deposition pattern was associated predominantly with mixed membranous and proliferating histomorphologic forms of GN. Subepithelial deposition pattem predominated in the class V. An average transformation rate for WHO classes and distribution pattem of immune deposits were 36% and 43.6%, respectively. The highest transformation rate were seen in histomorphologic types of GN ( 51.7%). In conclusion, WHO classification provide valuable information about disease subsets. However, it is important to evatuate also histomorphologic form because of significant heterogeneity inside WHO ctass III and IV, which may have prognostic and therapeutic implications.
Deskriptorji		GLOMERULONEPHRITIS LUPUS ERYTHEMATOSUS, SYSTEMIC FLUORESCENT ANTIBODY TECHNIQUE MICROSCOPY, ELECTRON IMMUNOLOGIC DISEASES LUPUS NEPHRITIS WORLD HEALTH ORGANIZATION