Avtor/Urednik		Putrino, I; Baccarini, P; Bračko, M; Foschini, MP; Collina, G
Naslov		Melanoma maligno con marcata reazione pseudoepiteliomatosa: descrizione di un caso
Prevedeni naslov		Primary malignant melanoma with pseudoepitheliomatous reaction marker: a case report
Tip		članek
Vir		Pathologica
Vol. in št.		Letnik 90, št. 4
Leto izdaje		1998
Obseg		str. 397-402
Jezik		ita
Abstrakt		Pseudoepitheliomatous hyperplasia or pseudocarcinomatous hyperplasia (PEH) is characterized by a downward expansion of the epidermis, which can simulate a squamous cell carcinoma (SC). It is usually associated to chronic inflammatory conditions, but rarely it can hide a tumour. In the present paper a case of melanoma (M) associated with a prominent PEH is described. The patient is a 79-year old woman who presented a polypoid, ulcerated lesion of the left thigh. The lesion was entirely removed. The patient is free of disease 5-years after surgery. On histology, the malignant melanomatous proliferation was closely admixed to sheets of squamous cells. The possibility of SC was excluded as the squamous component did not show architectural disarray, prominent nucleoli and atypical mitoses. Siringomatous metaplasia was observed in the deeper portion of the lesion. On the basis of these findings the diagnosis of melanoma (M) associated to prominent PEH was considered the most likely.
Deskriptorji		MELANOMA AGED CARCINOMA CARCINOMA, SQUAMOUS CELL HYPERPLASIA SKIN NEOPLASMS SKIN ULCER