Avtor/Urednik		Mrvič, Tatjana; Klen, Jasna
Naslov		Ocena uspešnosti dveh metod zdravljenja akutnega bronhiolitisa pri malih otrocih
Prevedeni naslov		Evaluation of the efficiency of two methods in treating acute bronchiolits in small children
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 38, št. 4
Leto izdaje		1999
Obseg		str. 473-83
Jezik		slo
Abstrakt		Abstract. Bronchiolitis is an acute respiratory disease of early childhood, mostly caused by respiratory syncytial virus. A blind prospective study was undertaken to determine the effects of corticosteroid therapy on the duration and prognosis of the disease in small children with a mild to moderate clinical picture of bronchiolitis. Also, we wished to assess the efficacy and saety of corticosteroids given for acute bronchiolitis and for subsequent post-bronchiolis wheezing. The study involved 44 previously healthy infants, aged 3-15 months. They were rendomised into two groups (n=22): one receiving corticosteroids and another given no corticosteroid therapy. The infants were evaluated by determinations of body weight and vital signs, and by rating of respiratory and auscultatory breathing. The medication given in the hospital was continued after discharge. There was no difference between the two groups in any of the parameters studied, but they differed significantly as concerns their respiratory rates observed 14 days after discharge from the hospital (3.74) (p < 0.0011 ). The use of corticosteroids in the treatment of acute bronchiolitis can shorten a prolonged subclinical course of the disease, but has no effect on the severity of illness or length of hospital stay.
Izvleček		Bronhiolitis je akutna respiratorna bolezen zgodnjega otroštva, v največjem odstotku povzročena z respiratornim sincicijskim virusom. Zaradi nasprotujočih si mnenj o koristnosti zdravljenja akutnega bronhiolitisa s kortikosteroidi sva izvedli slepo prospektivno študijo, s katero sva skušali oceniti vpliv kortikosteroidnega zdravljenja na trajanje in napoved poteka bolezni pri malih otrocih z blago do zmerno hudo obliko bronhiolitisa. V raziskavo je bilo vključenih 44 otrok, starih od 3 do 15 mesecev, ki so bili predhodno zdravi. Otroci so bili naključno razporejeni v dve skupini (n=22), od katerih je ena prejemala kortikosteroide, druga pa ne. Otrokom sva merili telesno težo, vitalne znake, dihalni napor in avskultatorni izvid. Po odpustu iz bolnišnice so otroci nadaljevali z enakim zdravIjenjem. Ponovno sva jih pregledali ambulantno čez 14 dni. Ugotovili sva, da ni nobene razlike med obema skupinama otrok v parametrih, ki sva jih opazovali, obstaja pa statistično pomembna razlika v frekvenci dihanja 3,74 (p < 0,0011 ) med skupinama 14 dni po odpustu iz bolnišnice. Kortikosteroidi lahko skrajšajo podaljšani subklinični potek bronhiolitisa, ne vplivajo pa na težo bolezni in trajanje bolnišničnega zdravljenja.
Deskriptorji		BRONCHIOLITIS, VIRAL ADRENAL CORTEX HORMONES INFANT ACUTE DISEASE FLUORESCENT ANTIBODY TECHNIQUE, DIRECT RESPIRATORY SYNCYTIAL VIRUS, HUMAN ADENOVIRUSES, HUMAN INFLUENZA A VIRUS, HUMAN LENGTH OF STAY SMOKING BREAST FEEDING BODY TEMPERATURE TREATMENT OUTCOME