Avtor/Urednik		Horvat-Žnidaršič, Irena; Šuput, Dušan; Gubenšek, Franc
Naslov		The effect of ammodytin L on frog neuromuscular junction
Tip		članek
Vir		Pflugers Arch
Vol. in št.		Letnik 439, št. 3 Suppl
Leto izdaje		2000
Obseg		str. R102-3
Jezik		eng
Abstrakt		Effects of myotoxic ammodytin L on frog neuromuscular junction were examined by morphological, enzymatic and electrophysiological studies. Electron micrographs of the frog neuromuscular junction revealed destruction of muscle fibers. Nerve terminals seemed to remain intact. The activity of the muscle specific enzymes in the bathing solution rose with time in a dose-dependent manner. Ammodytin L depressed the response of the neuromuscular preparation to acetylcholine. Measurements of electrically triggered isometric muscle contractions show that the toxin depresses the neuromuscular transmission both in the curarised and in the untreated frog neuromuscular preparation with marked difference between the time-courses of both effects, indicating that neurotoxic effect may also be involved.
Deskriptorji		VIPER VENOMS RANIDAE NEUROMUSCULAR JUNCTION ACETYLCHOLINE MUSCLE CONTRACTION MICROSCOPY, ELECTRON LACTATE DEHYDROGENASE CREATINE KINASE TUBOCURARINE