Avtor/Urednik		Trontelj, JV
Naslov		Single fiber electromyography: jitter measurement by axonal stimulation
Tip		članek
Vir		In: Anonymous DB, editor. Neuromuscular transmission testing. Teaching course no. 9. 11th International congress of EMG and clinical neurophysiology; 1999 Sep 7-11; Prague; Czech Republic. Prague: ?,
Leto izdaje		1999
Obseg		str. 40-51
Jezik		eng
Abstrakt		This text describes the techniques for performing jitter study by axonal microstimulation, one of the most common applications of Single Fibre Electromyography (SFEMG). Only the essential guidelines are given. For details, see Stalberg and Trontelj 1994 or Trontelj and Stalberg 1992. Stimulation SFEMG has evolved into a useful modification of the original method introduced in the 60s by Ekstedt and Stalberg. It is based on a combination of well controllable, highly selective activation with highly selective recording. Among the advantages of the method is its greater precision, since only single neuromuscular junctions rather than pairs are studied, and the often disturbing effect of muscle fiber velocity recovery function can be eliminated. The main use of stimulation SFEMG is in the diagnosis of neuromuscular transmission disorders, in which it offers high sensitivity (over 95%). Moreover, the study of individual neuromuscular junctions at different stimulation rates may help in differentiation between the pre- and postsynaptic abnormalities. The method is suitable to detect muscle fiber splitting, a common finding in certain neuromuscular disorders. Direct intrafascicular muscle fiber stimulation allows precise measurement of propagation velocity (a function of muscle fiber diameter) and its recovery function (abnormal in muscular dystrophies). The phenomenon of action potential recovery function may provide a useful and sensitive parameter in eval;uating depolarisation-repolarisation abnormalities, such as in genetically determined or drug-induced myotonic disorders. Myogenic block of conduction can be detected in sarcolemmal ion channel abnormalities. (Abstract truncated at 2000 characters).
Deskriptorji		NEUROMUSCULAR JUNCTION SYNAPTIC TRANSMISSION ELECTROMYOGRAPHY MUSCLE FIBERS