Avtor/Urednik		Zakotnik, Branko
Naslov		Zdravljenje neoperabilnih karcinomov glave in vratu z obsevanjem in hkratno kemoterapijo
Prevedeni naslov		Treatment of inoperable head and neck cancer with radiotherapy and concomitant chemotherapy
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		1999
Obseg		str. 82
Jezik		slo
Abstrakt		Introduction: The incidence of head and neck cancer in Slovenia is high, and in more than half of the patients the tumor is inoperable at the time of diagnosis. Despite the treatment with radiotherapy the survival in this unfavourable group of patients is dismal. Treatment of these patients with chemotherapy before irradiation did not improve their survival, but it might be improved with concomitant treatment with chemotherapy and irradiation. Purpose: To compare the efficacy of concomitant irradiation with Mitomycin C and Bleomycin in patients with inoperable head and neck carcinoma with radiotherapy alone. Patients and methods: Between March 1991 and December 1993, 64 patients with inoperable head and neck carcinoma (41 with oropharyngeal site) were randomized to radiotherapy alone (group A) or radiotherapy combined with simultaneous application of Mitomycin C and Bleomycin (group B). In both groups patients were irradiated five times weekly with 2 Gry to a total dose of 66-70 Gry. The planned concomitant treatment in group B was: Bleomysin 5 mg twice a week IM, total dose 70 mg, Mitomycin C 15 mg/m2 IV after delivery of 10 Gry, and 10 mg/m2 iv on the last day of radiotherapy. To enhance the effect of these two drugs, patients received also Nicotinamide, Clorpromazine and Dicoumarol. Because significantly better results were achieved in arm B for patients with inoperable oropharyngeal carcinoma, the study was closed and such patients were after December 1993 routinely treated with the combined therapy (as in arm B). Until October 1996 we treated and followed up 48 such consecutive patients. Even after these period we use the same combined treatment for patients with inoperable oropharyngeal carcinoma. (Abstract truncated at 2000 characters).
Deskriptorji		HEAD AND NECK NEOPLASMS NEOPLASM STAGING OROPHARYNGEAL NEOPLASMS MITOMYCIN C BLEOMYCIN PROSPECTIVE STUDIES RANDOMIZED CONTROLLED TRIALS SURVIVAL ANALYSIS