Avtor/Urednik		Strojan, Primož
Naslov		Katepsin D in rak dojke
Prevedeni naslov		Cathepsin D and breast cancer
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 69, št. 2
Leto izdaje		2000
Obseg		str. 101-5
Jezik		slo
Abstrakt		Background. Aspartic proteinase cathepsin D is an ubiquitous lysosomal proteolytic enzyme. The potential role of cathepsin D as a prognostic factor of the disease in cancer patients is determined by its involvement in proteolytic processes leading to the invasion and metastazing of tumor cells. The paper gives the description of biochemical properties of the enzyme and of its role in the cell as well as in the malignant tumors growth and metastasizing. The paper also provides a detailed review of the clinical studies dealing with the prognostic value of cathepsin D in breast cancer patients; a particular attention is paid to certain unresolved questions and dilammas as exposed in the so far published studies. Conclusions. Despite the viewpoint that high content of cathepsin D in the tissue of breast carcinoma may prognosticate lower survival of the patients, the knowledge on the cathepsin D gathered so far is not sufficently conclusive to make more detailed estimate of its prognostic vallue in this particular cancer type. Therefore, in every day clinical practice, cathepsin D is not included in the treatment plans of breast cancer patients.
Izvleček		Izhodišča. Aspartatna proteinaza katepsin D je ubikvitarni lizosomski proteolitični encim. Možna vloga katepsina D kot kazalnika za napoved poteka bolezni pri bolnikih z rakom temelji na njegovi vpletenosti v proteolitične procese, ki vodijo v invazijo in zasevanje tumorskih celic. V prispevku so opisane biokemične lastnosti encima, njegova vloga v celici ter pri rasti in zasevanju malignih tumorjev. Podan je podrobnejši pregled kliničnih raziskav, ki obravnavajo napovedni pomen katepsina D pri bolnicah s karcinomom dojke; posebej so poudarjena nerešena vprašanja in dileme, ki jih izpostavljajo rezultati do sedaj objavljenih študij. Zaključki. Kljub mnenju, da visoka vsebnost katepsina D v tkivu karcinoma dojke napoveduje slabše preživetje bolnic, pa so za natančnejšo opredelitev njegove napovedne vloge pri tej vrsti raka današnja spoznanja še premalo konkluzivna. Zato pri načrtovanju zdravljenja bolnic s karcinomom dojke kapepsina D ne uporabljamo v vsakodnevni klinični praksi.
Deskriptorji		BREAST NEOPLASMS CATHEPSIN D PROGNOSIS NEOPLASM STAGING