| Avtor/Urednik | Burja, S | |
| Naslov | Vpliv kisika na izločanje rastnih faktorjev žilnega endotelija in retinopatija nedonošenčkov | |
| Prevedeni naslov | Regulation of vascular endothelial growth factors by oxygen and retinopathy of prematurity | |
| Tip | članek | |
| Vir | Slov Pediatr | |
| Vol. in št. | Letnik 7, št. Suppl 1 | |
| Leto izdaje | 2000 | |
| Obseg | str. 204-7 | |
| Jezik | slo | |
| Abstrakt | Background: Retinopathy of prematurity with uncontrolled neovascularization is usually initiated by hypoxia. During the past four decades, researchers all over the world have elaborated numerous hypotheses on retinal cell secretion of substances triggering neovascularization as a response to defective oxygenation. At the same time they hypothesized on the clear association of hypoxia with the interruption of normal vascularization and its obliteration. Detected were vascular endothelial growth factors responsible for normal retinal vessel development. Some promotors and some inhibitors of vascular endothelial growth factor secretion were also detected. Angiogenesis in the retina of a premature infant is a complicated multistage process involving various factors. All that affects the balance between stimulation and inhibition of vascularization has not been elucidated. Method: A summary of the results of the newest studies regarding the etiopathogenesis of retinopathy of prematurity. Conclusion: The results of the newest studies regarding the etiopathogenesis of retinopathy of prematurity have contributed considerably to the clarification of the development of the disease. However the mechanisms leading to the interruption of normal retinal vascularization and to vasoobliteration have still not been elucidated. We are approaching the moment when the medical intervention allowing the prevention of premature retinopathy will be defined. | |
| Izvleček | Izhodišče: Hipoksija običajno spodbudi nenadzorovano razraščanje novega žilja očesne mrežnice nedonošenčka. V zadnjih štirih desetletjih so raziskovalci širom sveta izdelali veliko hipotez o tem, kako mrežnica izloča snovi, ki sprožijo razraščanje novih žil kot odgovor na pomanjkljivo oskrbo s kisikom. Hkrati so bile postavljene hipoteze o jasni povezavi med hiperoksijo ter prekinitvijo normalnega razvoja žilja in njegovo obliteracijo. Odkrili so rastne faktorje žilnega endotelija, odgovorne za normalen razvoj mrežničnega žilja. Odkrili so tudi nekatere pospeševalce in nekatere zaviralce izločanja rastnih faktorjev žilnega endotelija. Angiogeneza na mrežnici očesa nedonošenčka je zapleten večstopenjski proces, v katerem sodelujejo različni dejavniki. Kaj vse lahko spremeni ravnotežje med stimulacijo in inhibicijo razvoja žilja še ni raziskano. Metoda: Povzetek rezultatov najnovejših raziskav etiopatogeneze retinopatije nedonošenčkov. Zaključek: Rezultati najnovejših raziskav etiopatogeneze retinopatije nedonošenčkov so razvoj bolezni dokaj razjasnili, še vedno pa niso povsem razjasneni mehanizmi, ki vodijo v prekinitev normalnega razvoja mrežničnih žil in v vazoobliteracijo. Vse bližje smo trenutku, ko bo opredeljen medicinski poseg, s katerim bo mogoče razvoj prematurne retinopatije preprečiti. | |
| Deskriptorji | RETINAL DISEASES ENDOTHELIAL GROWTH FACTORS OXYGEN INHALATION THERAPY INFANT INFANT, PREMATURE, DISEASES |