| Avtor/Urednik | Bohuslavizki, Karl H; Klutmann, Susanne; Bruns, Juergen; Kroeger, Sabine; Bleckmann, Christian; Buchert, Ralph; Dobrowolskij, Dimitrij; Mester, Janos; Clausen, Malte | |
| Naslov | Value of 18F-FDG-PET in clinical management of patients with osteosarcoma | |
| Prevedeni naslov | Pomen 18F-FDG-PET pri vodenju bolnikov z osteosarkomom | |
| Tip | članek | |
| Vir | Radiol Oncol | |
| Vol. in št. | Letnik 34, št. 1 | |
| Leto izdaje | 2000 | |
| Obseg | str. 11-9 | |
| Jezik | eng | |
| Abstrakt | The aim of this study was to define the value of 18F-FDG PET in clinical management of patients with osteosarcoma based on current treatment regimen. Patients and methods. A total of 18 patients (4 female, 14 male) aged from 14 to 63 years with primary osteosarcoma (n=6) or suspect for relapse of osteosarcoma (n=12) were investigated retrospectivety. First, all patients underwent conventional diagnostic work-up, i.e. X-ray and MRI of the primary bone lesion, CT scan of the chest as well as conventional bone scan. In addition, whole-body PET-images were acquired on an ECAT EXACT 47 (921) with an axial field-of-view of 16.2 cm (Siemens, CTI) after intravenous injection of 370 MBq18F FDG. All tumor-suspicious PET findings were evaluated histologically. Results of histology, PET findings and conventional imaging were correlated on a lesion-by-lesion basis. Results. 18F-FDG-PET clearly depicted all primary osteosarcomas in 6 patients and a relapse of osteosarcoma in two patients. In the remaining 10 patients histology could not confirm a relapse of osteosarcoma. Eight out of 18 patients showed further lesions with an abnormal 18F-FDG-uptake. These lesions were predominantly located in the lung (n=5), in the skeleton (n=3), and in the inguinal region (n=1). Three of 8 patients had primary diagnosis of osteosarcoma and 5 were suspected to have tumor relapse. All lesions but the lesion of the inguinal region turned out to be metastases of osteosarcoma. However, therapeutic management must be taken into consideration when interpreting these encouraging results. Since the vast majority of patients are known to have micro metastases at the time of diagnosis, combined treatment consisting of neoadjuvant chemotherapy and surgical resection of the tumor is the standard treatment. Thus, 18F FDG-PET has no significant impact in primary diagnosis of osteosarcoma. (Abstract truncated at 2000 characters.) | |
| Izvleček | Izhodišča. Namen te študije je bil ovrednotiti uporabnost 18F-FDG-PET pri zdravljenju bolnikov z osteosarkomom, ki temelji na sedanjih režimih zdravljenja. Bolniki in metode. Retrospektivno smo raziskali 18 bolnikov (4 ženske, 14 moških) starih med 14 in 63 let z primarnim osteosarkomom (n=6) ali sumom na relaps osteosarkoma (n=12). Pri vseh bolnikih smo najprej opravili konvencionalno diagnostiko (RTG in MRI primarne kostne lezije, CT toraksa in konvencionalni scintigram kosti). Dodatno smo napravili še PET celega telesa na ECAT EXACT 47 (921) z aksialnim vidnim poljem 16.2 cm (Siemens, CTI) po intravenozni aplikaciji 370 MBq 18F-FDG. Vse za tumor sumljive izvide PET smo ocenili histološko. Izvide histologije, PET in konvencionalne diagnostike smo korelirali lezijo po lezijo. Rezultati. 18F-FDG-PET je jasno prikazal vse primarne osteosarkome pri šestih bolnikih in relaps osteosarkoma pri dveh bolnikih. Pri osmih izmed 18 bolnikov je prikazal še druge lezije z nenormalnim privzemom 18F-FDG. Te lezije so bile v glavnem locirane v pljučih (n=5), okostju (n=3) in v ingvinalni regiji (n=1). Te lezije so se nahajale pri treh bolnikih s primarno diagnozo osteosarkoma in pri petih bolnikih z sumom na relaps osteosarkoma. Vse razen lezije ingvinalno so bile potrjene kot metastaze osteosarkoma. Pri interpretaciji teh vzpodbudnih rezultatov moramo upoštevati zdravljenje bolnikov. Ker vemo, da ima večina bolnikov ob diagnozi prisotne mikrometastaze, je standardno zdravljenje neoadjuvantna kemoterapija in kirurška resekcija tumorja. Tako 18F-FDG-PET nima pomemnega vpliva pri primarni diagnozi osteosarkoma. (Izvleček prekinjen pri 2000 znakih.) | |
| Deskriptorji | OSTEOSARCOMA TOMOGRAPHY, EMISSION-COMPUTED TREATMENT OUTCOME DEOXYGLUCOSE FLUORINE NEOPLASM STAGING BIOPSY |