Avtor/Urednik		Drusany, Kristina
Naslov		Vpliv plazminogena in plazmina v folikularni tekočini na ovulacijo
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		1999
Obseg		str. 26
Jezik		slo
Abstrakt		In Department of obstetrics, Ljubljana, Medical Center introduced in the year 1992/93 preventive follicular punction (ETFA) 10-12 hours after administration of human chorionic gonadotrophin (hCG). With that procedure is successfully prevented severe ovarian hyperstimulation syndrome (OHSS). 36 hours after induction of ovulation with hCG they aspirate mature oocits. These are afterwards used in in vitro fertilization. Because OHSS is life treatening for patients (severe form occurs in 0,5-2%) we are trying to understand its pathogenesis better. With this we could help in prevention of this study. The aim of the study was to find out the presence and difference in concentration of plasminogen and indirectly also plasmin 12 and 36 hours after induction with hCG. 23 follicular fluids involved in our study, from women, who were treated because of infertility (aged less than 35 years) in Gynecological department of Medical center in Ljubljana. Plasminogen was measured with Berichrom plasminogen (Behring, Marburg - Lahn, Germany). The fallowing observations were found - the presence of plasminogen in follicular fluid was determined, - there was no significant difference between concentrations of plasminogen 12 and 36 hours after induction of ovulation with hCG. With regard to results we can assume that in case of induced ovulation with hCG plasminogen/plasmin system is not that important as we suspected.
Deskriptorji		PLASMIN PLASMINOGEN OVULATION INDUCTION GONADOTROPINS, CHORIONIC FOLLICULAR FLUID OVARIAN HYPERSTIMULATION SYNDROME