Avtor/Urednik		Sterle, Nadja
Naslov		Korelacija radiosenzitivnosti tumorjev in vitro in in vivo
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Visoka šola za zdravstvo
Leto izdaje		1999
Obseg		str. 35
Jezik		slo
Abstrakt		Radiotherapy is a part of medicine, which uses effects of radiation for the therapeutic purpose. Treatment is in most cases locally limited to malignoma. Predictive assays are of great importance for planning the optimal radiotherapeutic treatment. Beside of physiologic properties of tumors, the tumor cells radiosensitivity is the most important predictive factor for the response to the therapy. Object of the work was to assess the applicability of in vitro test as predictive assays for the results of radiotherapy of the same tumor models in vivo. Radiosensitivity of sarcoma LPB, fibrosarcoma SA-1 and melanoma B16F1, which were treated in vitro and in vivo, was compared. For all three cell lines the cell surviving curves and a/b ratios were obtained. Those can be used for predicting results in clinical use. In in vivo assays the success of therapy was stated by the tests of local control of tumor growth. Doses of radiation, which control the growth of 50% of tumors were different for different types of radiation. Results of the work partially confirm correlation of radiosensitivity for tumors treated in vitro and in vivo. Different cell surviving curves show different reactions to radiation. The use of predictive assays for radiotherapy planning is reasonable.
Deskriptorji		NEOPLASMS RADIATION TOLERANCE