Avtor/Urednik		Štiblar-Martinčič, Draga
Naslov		Morfološke značilnosti Langerhansovih celic
Prevedeni naslov		Morphological characteristics of Langerhans cells
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 39, št. 1
Leto izdaje		2000
Obseg		str. 79-83
Jezik		slo
Abstrakt		Langerhans cells are part of the widely distributed antigen-presenting cells known as dendritic cells with a key role in immune responses. These specialised bone marrow-derived cells were originally found in the epidermis and later demonstrated in the mucosa of other organs. Langerhans cells are difficult to identifiy in sections stained with hematoxylin-eosin. A large number of surface and/or cytoplasmic antigens have been localised on Langerhans cells for immunohistochemical detection. The Birbeck granules are the specific markers of Langerhans cells on electron microscopical level. Langerhans cells represent the primary immune defence of the skin and mucosae with various immunological functions, among which the processing and presenting antigen to T lymphocytes are the most important.
Izvleček		Langerhansove celice so del obsežnega sistema antigen predstavitvenih celic, znanih pod imenom dendritične celice, ki imajo osrednjo vlogo pri imunskem odzivu. Prvotno so te specializirane celice, ki imajo izvor v kostnem mozgu, našli v povrhnjici, kasneje pa so jih prikazali tudi v sluznici različnih organov. V preparatih, obarvanih s hematoksilinom in eozinom, so Langerhansove celice v svetlobnem mikroskopu težje prepoznavne, dokažemo pa jih imunohistokemično na osnovi številnih površinskih in/ali citoplazmatskih antigenov. Specifičen označevalec za prepoznavo na elektronskomikroskopski ravni so Birbeckova zrnca. Langerhansove celice omogočajo primarno predelavo in predstavitev antigena limfocitom T v koži in sluznicah.
Deskriptorji		LANGERHANS CELLS BONE MARROW EPIDERMIS ANTIGEN-PRESENTING CELLS T-LYMPHOCYTES CYTOPLASMIC GRANULES MICROSCOPY, ELECTRON HEMATOXYLIN MACROPHAGES