Avtor/Urednik		Bricl, I; Glonar, L; Vogler, A
Naslov		Anti-D immunization prevention with antenatal RhD immunoprophylaxis and determination of the amount of fetomaternal hemorrhage after childbirth in Slovenia
Tip		članek
Vir		In: Novak-Antolič Ž, editor. Učinkovitost predporodnega varstva v Sloveniji. Zbornik prispevkov 7. Novakovi dnevi; 2000 jun 1-3; Moravske Toplice. Ljubljana: Slovensko zdravniško društvo, Združenje za perinatalno medicino,
Leto izdaje		2000
Obseg		str. 72-6
Jezik		eng
Abstrakt		Background. During pregnancy, anti-D antibodies cause the lysis of D-positive fetal erythrocytes, which may lead to anaemia, hydrops or even death of the fetus. RhD immunization can be prevented by consistent performance of ante- and postnatal immunoprophylaxis. Material and methods. The efficacy of protection of D-negative women in the period from 1954 to 1998 was established on the basis of the percentage of anti-D antibodies found during pregnancy or following delivery. The amount of fetomaternal haemorrhage was determined using the Kleihauer-Betke test in all D-negative pregnant women who delivered a D-positive newborn at the Division of Perinatology, Department of Obstetrics and Gynecology, Ljubljana Maternity Hospital (LMH) in the period from 1955 to 1999. Results. A decrease in the number of anti D-immunizations was found after the introduction of RhD prophylaxis after delivery, abortion and intrauterine procedures. By using the Kleihauer-Betke test fetomaternal haemorrhage exceeding 15 ml of fetal erythrocytes was found in 0.68% of D-negative women. Conclusion. It is expected that, in the future, consistent performance of antenatal RhD immuno-prophylaxis and determination of the amount of fetomaternal haemorrhage in all D-negative women after delivery of a D-positive newborn will additionally reduce the percentage of anti-D immunizations.
Deskriptorji		RH ISOIMMUNIZATION FETOMATERNAL TRANSFUSION ERYTHROBLASTOSIS, FETAL RHO(D) IMMUNE GLOBULIN