Avtor/Urednik		Peternel, Polona
Naslov		Dejavniki tveganja za nastanek venske tromboze
Prevedeni naslov		Risk factors for the development of venous thrombosis
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 39, št. Suppl 2
Leto izdaje		2000
Obseg		str. 3-8
Jezik		slo
Abstrakt		Acquired risk factors for venous thrombosis can be associated with physiological phenomena such as age, pregnancy and puerperium, diseases such as malignancies or antiphospholipid syndrome, as well as surgery, trauma, immobilisation, use of oral contraceptives and postmenopausal hormone replacement therapy. The genetic causes of venous thrombosis are protein C and S deficiency, antithrombin deficiency, factor V Leiden and prothrombin 20210A. Other plasma abnormalities, associated with the risk of thrombosis are a high level of Factor VIII, hyperhomocysteinemia and resistance to activated protein C not caused by Factor V Leiden.
Izvleček		Pridobljeni dejavniki tveganja za nastanek venske tromboze so povezani s fiziološkimi dogajanji, kot so staranje, nosečnost in poporodno obdobje, z boleznimi: rak in antifosfolipidni sindrom, z operacijami, poškodbami in imobilizacijo ter uporabo oralne kontracepcije in hormonskega nadomestnega zdravljenja v menopavzi. Med genetsko pogojene dejavnike tveganja uvrščamo pomanjkanje proteina C in S, antitrombina, faktor V Leiden in protrombin 20210A. Dejavnik tveganja za nastanek venske tromboze je tudi povečan faktor VIII in homocistein ter neodzivnost na aktivirani protein C ob odsotnem faktorju V Leiden.
Deskriptorji		THROMBOPHLEBITIS RISK FACTORS NEOPLASMS WOUNDS AND INJURIES AGE FACTORS IMMOBILIZATION CONTRACEPTIVES, ORAL PUERPERIUM PREGNANCY ESTROGEN REPLACEMENT THERAPY ANTIPHOSPHOLIPID SYNDROME PROTEIN C PROTEIN S ANTITHROMBINS FACTOR V FACTOR VII PROTHROMBIN