Avtor/Urednik		Stefanovski, Petar
Naslov		Prognostični dejavniki pri sarkomih mehkih tkiv
Prevedeni naslov		Prognostic factors in soft tissue sarcoma
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2000
Obseg		str. 126
Jezik		slo
Abstrakt		Background. A thorough understanding of the clinical and pathological factors that affect the outcome of soft tissue sarcomas is essential in formulating a treatment plan for patients with these tumors. Research on prognostic factors in soft tissue sarcomas is hampered by the enormous heterogeneity of these tumors, their relatively low incidence, and their unique and unpredictable behavior. Moreover, there is significant disagreement regarding their histogenesis and grading, as well as lack of consensus on the value of various prognostic factors. The first aim of this study was to show that grade, size, and stage have different prognostic significance for overall survival and distant recurrence than for local recurrence in patients with soft tissue sarcomas. The second aim was to identify other specific independent clinical and pathological prognostic factors for the end points of local recurrence, distant recurrence, post-metastasis survival, and overall survival in these tumors. Patients and methods. We analyzed data from 444 patients with primary soft tissue sarcomas with different localizations treated and followed-up at the Centro di Riferimento Oncologico, Aviano (Italy) from January 1985 to January 1997. Data of the patients were collected retrospectively and prospectively. Median follow-up time was 35.6 months. Median age of the patients was 53 years (range, 10 to 95 years). We analyzed prognostic value of age, sex, performance status (ECOG/WHO), hemoglobin value, localization, size, histopathologic type, grade (Broders), TNM stage (UICC/AJCC) for local recurrence, distant recurrence, post-metastasis survival and overall survival. We also analyzed the influence of local recurrence for distant metastasis, postmetastasis survival and overall survival, and the influence of distant metastasis for overall survival. (Abstract truncated at 2000 characters).
Deskriptorji		SOFT TISSUE NEOPLASMS SARCOMA PROGNOSIS NEOPLASM RECURRENCE, LOCAL SURVIVAL ANALYSIS NEOPLASM STAGING NEOPLASM METASTASIS SEX FACTORS AGE FACTORS