Avtor/Urednik		Sedmak, Boris
Naslov		Prostatični specifični antigen pri zgodnji diagnostiki karcinoma prostate
Prevedeni naslov		Prostatic specific antigen in the early detection of prostate cancer
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2000
Obseg		str. 89
Jezik		slo
Abstrakt		Background. Malignant diseases of the prostate gland are a major cause of morbidity and mortality in elderly men. In Slovenia, prostate cancer is the second most common malignancy in males over 65 years of age. An ideal treatment for prostate cancer has not been found, but total prostatectomy offers the only chance of complete cure for organ confined disease. Therefore, early detection is very important. The aim of the study was to improve the reliability of methods for the detection of early forms of prostate cancer, in order to reduce the number of negative biopsies and spare the patients invasive diagnostic evaluation. An additional goal was to account for the difference in the proportion of free PSA in prostate cancer compared to benign prostatic hyperplasia. Patients and methods. This prospective study included 454 patients who underwent ultrasound guided biopsy for an elevation in serum PSA or abnormality on digital rectal evaluation. Prostate volume and transition zone were measured with ultrasound. Serum total and free PSA level were determined, and the complexed PSA level, total PSA density, complexed PSA density, PSA density of transition zone, and percentage of free PSA in serum were calculated. Statistical analysis was done using Mann-Whitney U test. Receiver operating characteristic (ROC) curves were generated for each test. Further analyses were done comparing the ROC curves. Histological changes were evaluated in 391 tissue specimens removed by biopsy or on radical prostatectomy. A total of 147 specimens were examined by immunohistocemical methods to determine the presence and distribution of PSA and alpha1-antichymotrypsin. (Abstract truncated at 2000 characters).
Deskriptorji		PROSTATIC NEOPLASMS PROSTATE-SPECIFIC ANTIGEN BIOPSY PROSPECTIVE STUDIES PROSTATECTOMY ALPHA 1-ANTICHYMOTRYPSIN ROC CURVE HISTOCYTOCHEMISTRY