Avtor/Urednik		Ferluga, Dušan; Jerše, Maja; Vizjak, Alenka; Hvala, Anastazija; Rozman, Blaž; Kos-Golja, Mojca; Bren, Andrej F
Naslov		Correlation among WHO classes, histomorphologic patterns of glomerulonephritis and glomerular immune deposits in SLE
Tip		članek
Vir		Wien Klin Wochenschr
Vol. in št.		Letnik 112, št. 15-16
Leto izdaje		2000
Obseg		str. 692-701
Jezik		eng
Abstrakt		In addition to the conventional World health organization (WHO) classification of lupus glomerulonephritis (GN) various concomitant approaches have been introduced in the evaluation of renal biopsies of patients with systemic lupus erythematosus (SLE) in order to increase the impact of biopsies on the decision concerning the most approapriate therapy as well as for establishing the prognosis. Three hundred and seventy kidney tissue samples from 267 SLE patients were analysed using standardised light, electron and immunofluorescence microscopic techniques. In 155 patients, a comparative clinical follow-up study and statistical analysis were performed. The study highlighted the heterogeneity of WHO classes IV and III, which include 5 and 6 different conventional histomorphologic types of GN, respectively. Mixed membranous and proliferative GN associated with "full-house" mesangial-transmembranous immune deposits, demonstrated in more than one third of our SLE cases, appears to be diagnostically most characteristic. Immune deposits distributed in the glomeruli in five different patterns, obviously play a major role in the pathogenesis of various WHO classes and histomorphologic types of lupus GN. Additional mechanisms related to the occurrence of antiphospholipid antibodies and antineutrophil cytoplasmic antibodies are suggested to contribute to the histomorphologic heterogeneity of WHO class III and IV lupus GN, particularly to the development of thrombotic, necrotising and crescentic glomerular lesions. (Abstract truncated at 2000 characters).
Deskriptorji		LUPUS ERYTHEMATOSUS, SYSTEMIC LUPUS NEPHRITIS WORLD HEALTH ORGANIZATION BIOPSY PROGNOSIS IMMUNE COMPLEX DISEASES AUTOPSY CAUSE OF DEATH