Avtor/Urednik		Šipek-Dolničar, Alenka; Hojnik, Maja; Rozman, Blaž; Vizjak, Alenka; Ferluga, Dušan
Naslov		Small vessel thrombosis without major thrombotic events in systemic lupus erythematosus patients with antiphospholipid syndrome
Tip		članek
Vir		Wien Klin Wochenschr
Vol. in št.		Letnik 112, št. 15-16
Leto izdaje		2000
Obseg		str. 707-10
Jezik		eng
Abstrakt		Antiphospholipid syndrome has been defined by the presence of antiphospholipid antibodies or lupus anticoagulant in association with certain clinical events, including recurrent arterial or venous thromboses and recurrent fetal loss. It comprises two separate clinical entities: simple, characterized by large vessel occlusions, and catastrophic, with multiple occlusive events predominantly affecting small vessels. Three patients with systemic lupus erythematosus and permanently increased IgG anticardiolipin antibody levels are being described. Only postmortem histopathological examination revealed microangiopathic thrombotic changes in different organs, which were clinically silent in early stages of the disease and misinterpreted later in its course because of a peculiar clinical picture. All patients presented features of catastrophic antiphospholipid syndrome in the final stage of the disease.
Deskriptorji		LUPUS ERYTHEMATOSUS, SYSTEMIC ANTIPHOSPHOLIPID SYNDROME ANTIBODIES, ANTICARDIOLIPIN THROMBOPHLEBITIS ADOLESCENCE ADULT AUTOPSY PURPURA, THROMBOTIC THROMBOCYTOPENIC