Avtor/Urednik		Chabova, V; Tesar, V; Žabka, J; Rychlik, I; Merta, M; Jirsa, M Jr; Stejskalova, A; Stejskal, J
Naslov		Long term treatment of IgA nephropaty with cyclosporine A - a preliminary report
Tip		članek
Vir		In: Lindič J, Kaplan-Pavlovčič S, editors. Zbornik prispevkov 1. slovenski nefrološki kongres z mednarodno udeležbo; 1996 okt 23-26; Portorož. Ljubljana: Klinični center, Nefrološka klinika,
Leto izdaje		2000
Obseg		str. 39
Jezik		eng
Abstrakt		IgA nephropathy is the most common glomerulonephritis all over the world. Yet the standard treatment for the patients with progressive course and/or great proteinuria is currently lacking. We treated 6 patients (pts) with bioptically proven IgA nephropathy and proteinuria over 3.5 g/24 hrs with or without nephrotic syndrome and with serum creatinine less than 200 micromol/L and/or glomerulosclerosis less than 50% in renal biopsy who didn't respond to corticosteroids for at least 3 months. Pts were given cyclosporine A (CyA) in initial dose 5 mg/kg bw/day and than titrated to achieve the serum concentration of 70-150 ng/ml. Prednisone 5 mg on alternate days was given with cyclosporine. Proteinuria decreased during first month of therapy from 4.00 +- 0.48 g/day to 1.38 +- 0.29 g/day (p < 0.01) and remained low after one year of treatment (0.59 +- 0.14 g/day, p < 0.001). GFR (creatinine clearance) did not change during first month of therapy (1.25 +- 0.21 ml/s vs. 1.38 +- 0.29 ml/s), but slightly decreased after one year of treatment (1.05 +- 0.14 ml/s, p < 0.05). To assess the contribution of hemodynamic changes to the decrease of proteinuria we also calculated ratio of proteinuria to glomerular filtration rate (mg/1). This ratio was 40.64 +- 15.85 before therapy, it was significantly lower after one month (11.56 +- 3.24, p < 0.05) and after one year (6.78 +- 4.25, p < 0.01) of therapy. Serum cholesterol also significantly decreased during 12 months of therapy (6.21 +- 0.62 vs. 5.4 +- 0.45 mmol/L, p < 0.05). (Abstract truncated at 2000 characters.)
Deskriptorji		GLOMERULONEPHRITIS, IGA CYCLOSPORINE BIOPSY PROTEINURIA NEPHROTIC SYNDROME CREATININE TREATMENT OUTCOME