Avtor/Urednik		Vujkovac, Bojan; Lavre, Janez; Šabovič, Mišo
Naslov		Tranexamic acid in the treatment of bleeding in dialysis patients: our first experience
Tip		članek
Vir		In: Buturović-Ponikvar J, Bren AF, editors. Zbornik 2. slovenski nefrološki kongres z mednarodno udeležbo ob 30. letnici dialize in transplantacije ledvic v Sloveniji; 2000 sep 27-30; Brdo pri Kranju. Ljubljana: Klinični center, Klinični oddelek za nefrologijo,
Leto izdaje		2000
Obseg		str. 129-35
Jezik		eng
Abstrakt		Background. In patients with end stage renal disease, in the program of chronic haemodialysis, the bleeding is a common and potentially fatal complication arising from multiple acquired defects in hemostasis. The ability of tranexamic acid (TA), a potent antifibrinolytic agent, to stop serious bleeding in the dialysis patients was studied. Methods and results. During 57 months we treated 31 bleeding episodes (23 from upper gastrointestinal tract, 6 from lower gastrointestinal tract and 2 cerebral bleedings) in 16 dialysis patients. TA was used in the treatment of 6 episodes of serious bleeding from upper gastrointestinal, and 4 episodes from lower gastrointestinal tract and two cases of cerebral bleeding. The dosage schedule for TA was 20mg/kg body weight (mg/kg) intravenously followed by 10 or 20 mg/kg/48 hours orally for at least four weeks. No significant decrease in hemoglobin concentrations was observed in all treated cases of the upper gastrointestinal bleeding, while in the group of patients who did not received TA recurrent bleeding occurred in 4 patients (23,5%). Hemorrhages from lower gastrointestinal tract (colonic angiodysplasia) were all successfully treated with TA, but bleeding reappeared few months after treatment. Two treated patients with cerebral hemorrhage were comatose (Glasgow Coma Scale 7 and 5). In one case subdural and intracerebral haematomas resolved, whereas second patient with massive intracerebral hemorrhage died. Conclusions. Our first (nonrandomized) results suggest that TA could successfully stop the bleeding in dialysis patients. This remains to be confirmed in a further randomized study.
Deskriptorji		TRANEXAMIC ACID HEMODIALYSIS GASTROINTESTINAL HEMORRHAGE CEREBRAL HEMORRHAGE