Avtor/Urednik		Strojan, Primož; Popović, Mara; Jereb, Berta
Naslov		Secondary intracranial meningiomas after high-dose cranial irradiation: report of five cases and review of the literature
Tip		članek
Vir		Int J Radiat Oncol Biol Phys
Vol. in št.		Letnik 48, št. 1
Leto izdaje		2000
Obseg		str. 65-73
Jezik		eng
Abstrakt		Purpose: To review cases of secondary intracranial meningiomas following high-dose cranial irradiation (>=10 Gy) identified in Slovenia between 1968 and 1998, to determine their histological profile and to review the literature on this topic. Methods and Materials: Personal files of patients treated for secondary intracranial meningioma during a 1-year period were reviewed. In cases which met the criteria for radiation-induced tumors, steroid hormone receptor and Ki-67 status were analyzed. For the literature review, computerized database systems and reference lists from respective publications were used. Results: Five patients (2 females, 3 males), 3-11 years old at the time of cranial irradiation, developed secondary meningioma after a latency period of 9.5-31.5 years. Three patients had multiple tumors and 2 developed recurrent disease. Of 9 histologically examined tumors, 5 were graded as benign and 4 as atypical meningiomas, with Ki-67 proliferative index 3.2 +- 3.6 and 10 +- 6, respectively. The ratio between positive and negative meningiomas regarding immunostaining for progesterone and estrogen receptors was eight-to-one and six-to-three, respectively. Cumulative actuarial risk of secondary meningioma in a cohort of 445 children 16 years or younger treated with high-dose cranial irradiation between 1968 and 1990 in Slovenia at 10, 20, and 25 years was 0.53%, 1.2%, and 8.18%, respectively. Out of 126 cases of radiation-induced meningiomas reported, 57% were females and 43% were males, with mean age at presentation 33+-17.3 years. The majority (68%) of patients was irradiated during childhood. The latency period was significantly shorter in those who aged 5 years or less at the time of cranial irradiation (p = 0.04), and in those with atypical/anaplastic tumor (p = 0.01). Correlation between radiation dose and latency period could not be found. (Abstract truncated at 2000 characters.)
Deskriptorji		MENINGEAL NEOPLASMS MENINGIOMA CRANIAL IRRADIATION NEOPLASMS, RADIATION-INDUCED NEOPLASMS, SECOND PRIMARY CHILD CHILD, PRESCHOOL BRAIN NEOPLASMS LEUKEMIA, LYMPHOCYTIC, ACUTE MEDULLOBLASTOMA KI-67 ANTIGEN NEOPLASM PROTEINS RECEPTORS, ESTROGEN RECEPTORS, PROGESTERONE