Avtor/Urednik		Debeljak, Nataša; Majdič, Gregor; Haugen, Trine B; Waterman, Michael R; Rozman, Damjana
Naslov		Why is cholesterogenic lanosterol 14alpha-demethylase (CYP51) highly expressed in germ cells of the testis?
Tip		članek
Vir		In: Okamoto M, Ishimura Y, Nawata H, editors. Molecular steroidogenesis. Proceedings of the Yamada conference LII on molecular steroidogenesis held: frontiers science series no. 29; 1999 Aug 25-28; Nara. Tokyo: Universal academy press,
Leto izdaje		2000
Obseg		str. 219-20
Jezik		eng
Abstrakt		Lanosterol 14alpha-demethylase (CYP51) is gene of the postsqualene part of cholesterol biosynthesis, with the highest level of expression in the testis. CYP51 expression is upregulated >10-fold in spermatids compared to premeiotic germ cells while two genes subsequent to CYP51 in the pathway (sterol delta 8,7 - isomerase and sterol delta 7 - reductase) remain exoressed at low levels. CYP51 and squalene synthase proteins are not coordinately expressed in all stages of spermatogenesis. We propose that the discordant expression of late cholesterogenic genes in spermatids is responsible for accumulation of FF-MAS.
Deskriptorji		LANOSTEROL CYTOCHROME P-450 CHOLESTEROL GERM CELLS GENE EXPRESSION TESTIS SQUALENE SYNTHETASE NADPH-FERRIHEMOPROTEIN REDUCTASE MEIOSIS RNA, MESSENGER