Avtor/Urednik		Andoljšek, Dušan
Naslov		En sam odmerek rekombinantnega faktorja VII za izdrtje zoba pri prirojenem pomanjkanju faktorja VII
Prevedeni naslov		Single dose of recombinant factor VII for dental extraction in congenital factor VII deficiency
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 39, št. Suppl 5
Leto izdaje		2000
Obseg		str. 35-7
Jezik		slo
Abstrakt		Purpose. Dental extraction in hemophilia patients can safely be managed with preoperative coagulation factor concentrate and an antifibrinolytic, followed by antifibrinolytic for a week. It is assumed the same procedure can also be used in congenital factor VII deficiency. Patient and method. In 49 yr old man with congenital factor VII deficiency (F VII 0.02, prothrombin time 0.17 (normal 0.7- 1.2)) the sixth lower right tooth was extracted. 2400microg (20 microg/kgbw) of rF VIIa (NovoSeven, Novo Nordisk) and tranexamic acid 500 mg were given preoperatively, followed by tranexamic acid 500 mg four times a day for one week. F VII rose to 1.0 and prothrombin time to 1.0. Both values were the same 2 hours after the tooth exctraction, 24 hrs later F VII and prothrombin time were at basal level. There was no bleeding. Discussion and summary. Dental extraction in hemophilia patients can be managed with coagulation factor concentrate and antifibrinolytic preoperatively, followed by antibrinolytic until the wound heals. The same treatment method was successfully tested in congenital F VII deficiency. Such treatment is safer, cheaper and more simple than an infusion or a several- day repeated dose therapy. According to our knowledge this description of such a treatment is the first one.
Izvleček		Uvod. Za izdrtje zoba pri hemofiliku damo koncentrat koagulacijskega faktorja in antifibrinolitik predoperativno, po posegu pa antifibrinolitik per os do zaceljenja rane. Domnevamo, da bi podobno lahko ravnali pri osebah s prirojenim pomanjkanjem F VII. Bolnik in metoda. 49-letnemu VŠ s prirojenim pomanjkanjem faktorja VII (F VII 0.02, protrombinski čas 0,17 (normalno 0,7-1,2)) so izruvali spodnjo desno šestico. Pred posegom je dobil 2,4 mg (20 microg/kg telesne teže) rF VIIa (NovoSeven, Novo Nordisk) in 500 mg traneksamske kisline (Cyclocapron), zatem pa traneksamsko kislino per os 500 mg vsakih šest ur, do zaceljenja rane. F VII je porastel na 1,0, protrombinski čas 1,0. Dve uri po dajanju zdravil in posegu so bile vrednosti, 24 ur zatem pa izhodiščne. Krvavitve ni bilo. Razprava in zaključek. Za izdrtje zoba pri hemofiliji je ustaljeno dajanje koncentrata koagulacijskega faktorja in antifibrinolitika do zaceljenja rane. Poskus enakega zdravljenja pri prirojenem pomanjkanju F VII je bil uspešen. Gre za prvi opis takega zdravljenja.
Deskriptorji		FACTOR VII DEFICIENCY FACTOR VII TOOTH EXTRACTION MIDDLE AGE