| Avtor/Urednik | Bricl, Irena; Vogler, Andrej | |
| Naslov | Preprečevanje imunizacij anti-D z imunoprofilakso RhD | |
| Prevedeni naslov | Prevention of anti-D immunization with RhD immunoprophylaxis | |
| Tip | članek | |
| Vir | Med Razgl | |
| Vol. in št. | Letnik 39, št. Suppl 5 | |
| Leto izdaje | 2000 | |
| Obseg | str. 195-8 | |
| Jezik | slo | |
| Abstrakt | Background. During pregnancy, anti-D antibodies cause the lysis of D positive fetal erythrocytes, which may lead to anaemia, hydrops or even death of the fetus. RhD immunization can be prevented by consistent performance of ante- and postnatal immunoprophylaxis. Material and methods. The efficacy of protection of D negative women in the period from 1954 to 1998 was established on the basis of the percentage of anti-D antibodies found during pregnancy or following delivery. The amount of fetomaternal haemorrhage was determined using the Kleihauer-Betke test in all D negative pregnant women who delivered a D-positive newborn at the Ljubljana Maternity Hospital in the period from 1955 to 1999. Results. A decrease in the number of anti-D immunizations was found after the introduction of RhD prophylaxis after delivery, abortion and intrauterine procedures. By using the Kleihauer-Betke test, fetomaternal haemorrhage exceeding 15 ml of fetal erythrocytes was found in 0.68% of D negative women. Conclusion. It is expected that, in the future, consistent performance of antenatal RhD immunoprophylaxis and determination of the amount of fetomaternal haemorrhage in all D negative women after delivery of a D positive newborn, will additionally reduce the percentage of anti-D immunizations. | |
| Izvleček | Izhodišča. Protitelesa anti-D med nosečnostjo povzročajo razgradnjo D-pozitivnih plodovih eritrocitov, kar ima lahko za posledico slabokrvnost, hidrops ali celo smrt ploda. Imunizacijo RhD lahko preprečimo z doslednim izvajanjem pred- in poporodne imunoprofilakse RhD. Material in metode. Uspešnost zaščite D-negativnih žensk smo ugotavljali na osnovi deleža odkritih protiteles anti-D med nosečnostjo oz. po porodu v obdobju 1954-1998. Količino fetomaternalne krvavitve smo določili s testom Kleihauer-Betke pri vseh D-negativnih nosečnicah, ki so rodile D-pozitivnega otroka v ljubljanski porodnišnici v letih 1995-1999. Rezultati. Ugotovili smo padec imunizacij anti-D po uvedbi imunoprofilakse RhD po porodih, splavih in znotrajmaterničnih posegih. S testom Kleihauer-Betke smo ugotovili fetomaternalno krvavitev, večjo od 15 ml plodovih eritrocitov, pri 0,68 % porodnic. Zaključek. Pričakujemo, da bo v prihodnje dosledno izvajanje predporodne imunoprofilakse RhD in določanje količine fetomaternalne krvavitve pri vseh D-negativnih otročnicah, ki bodo rodile D-pozitivnega otroka, dodatno znižalo delež imunizacij anti-D. | |
| Deskriptorji | RH ISOIMMUNIZATION RH ISOIMMUNIZATION RHO(D) IMMUNE GLOBULIN PREGNANCY ERYTHROBLASTOSIS, FETAL |